Blood clotting factor IX Kashihara: amino acid substitution of valine-182 by phenylalanine.

Blood clotting factor IX Kashihara: amino acid substitution of valine-182 by phenylalanine. Research Abstract Details 

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Blood clotting factor IX Kashihara: amino acid substitution of valine-182 by phenylalanine. Abstract Text:

T Sakai,A Yoshioka,K Yamamoto,K Niinomi,Y Fujimura,H Fukui,T Miyata,S Iwanaga,

Hemophilia B Kashihara is a severe hemorrhagic disorder in which the factor IX antigen is present in normal amounts but factor IX biological activity is markedly reduced. In addition, purified factor IX Kashihara is not activated by purified factor XIa in the presence of calcium ions. Amino acid sequence analysis of one of the tryptic peptides isolated from factor IX Kashihara indicated that Val-182 (equivalent to Val-17 in the chymotrypsin numbering system) had been replaced by Phe. No substitution was found in the members of the catalytic triad His-221, Asp-269, and Ser-365 of factor IX Kashihara. The Val-to-Phe replacement found in factor IX Kashihara appears to sterically hinder the cleavage of Arg 180-Val 181 by factor XIa required for the activation of this zymogen.

Blood clotting factor IX Kashihara: amino acid substitution of valine-182 by phenylalanine. Publishing Authors By Initials

T Sakai,A Yoshioka,K Yamamoto,K Niinomi,Y Fujimura,H Fukui,T Miyata,S Iwanaga,

For similar amino acids, peptides, and proteins: amino acids: amino acids, branched-chain: valine research abstracts see: amino acids, peptides, and proteins: amino acids: amino acids, branched-chain: valine research

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Blood clotting factor IX Kashihara: amino acid substitution of valine-182 by phenylalanine. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 105

Page Numbers: 756-9

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: May

YEAR: 1989

Blood clotting factor IX Kashihara: amino acid substitution of valine-182 by phenylalanine. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Blood clotting factor IX Kashihara: amino acid substitution of valine-182 by phenylalanine. Keywords Mesh Terms:

KEYWORDS: Valine

MESH TERMS: analysis

Chemical & Substance for Abstract: Blood clotting factor IX Kashihara: amino acid substitution of valine-182 by phenylalanine. Information

Substance Name: Trypsin

Registry Number: EC 3.4.21.4

Grant and Affiliation Information for Blood clotting factor IX Kashihara: amino acid substitution of valine-182 by phenylalanine.

AFFILIATION: Department of Pediatrics, Nara Medical College.

Country: JAPAN

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MEDLINETA: J Biochem

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