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Blood cells and coagulation during experimental lung insufficiency in dogs.

Blood cells and coagulation during experimental lung insufficiency in dogs. Research Abstract Details 

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  • Blood cells and coagulation during experimental lung insufficiency in dogs. Abstract Text:

    i guldvogI Guldvog,o d saugstadO D Saugstad,a o aasenA O Aasen,j daleJ Dale,b liumB Lium,m larsbraatenM Larsbraaten,k lyngaasK Lyngaas,e amundsenE Amundsen,

    Thromboembolism of minor vessels in the lungs is almost constantly seen in posttraumtic lung insufficiency. Many investigators consider it as the primary factor in the pathogenesis of this condition. The present paper deals with screening of the coagulation system as part of a more extended project also investigating changes in the fibrinolytic system and the kallikrein-kinin system. The data are also to be compared with morphological findings during the development of experimental posttraumatic lung insufficiency. The experimental syndrome was evoked in Labrador retriever dogs by haemorrhagic hypotension combined with clamping of the portal triad. The surgical procedure was extended to additional thoracotomy in one group of dogs. Group I, without thoracotomy, were followed for 12 hours. Group II, with thoracotomy, were followed until they succumbed (3-14 hours). Thrombotest (TT) showed a steady prolongation of clotting time in both groups, whereas Cephotest did not reveal any alterations, except for a significant prolongation in group II just before collapse. Fibrinogen was markedly reduced in both groups. Platelets and leucocytes were significantly reduced, but only in group II. It is concluded that the present data are indicative of disseminated intravascular coagulation. The involvement of the intrinsic coagulation system is questioned.

    Blood cells and coagulation during experimental lung insufficiency in dogs. Publishing Authors By Initials

    i guldvogI Guldvog,od saugstadOD Saugstad,ao aasenAO Aasen,j daleJ Dale,b liumB Lium,m larsbraatenM Larsbraaten,k lyngaasK Lyngaas,e amundsenE Amundsen,

    For similar respiratory tract diseases: lung diseases: respiratory distress syndrome, adult research abstracts see: respiratory tract diseases: lung diseases: respiratory distress syndrome, adult research

    PUBMED ID PMID:

    MEDLINE DATE:

    Blood cells and coagulation during experimental lung insufficiency in dogs. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Acta chirurgica Scandinavica. Supplementum

    VOLUME: 499

    Page Numbers: 131-9

    Journal Abbreviation:

    ISSN: 0301-1860

    DAY: 6

    MONTH: 12

    YEAR: 1980

    Blood cells and coagulation during experimental lung insufficiency in dogs. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 370305

    Blood cells and coagulation during experimental lung insufficiency in dogs. Keywords Mesh Terms:

    KEYWORDS: Respiratory Distress Syndrome, Adult

    MESH TERMS: pathology

    Chemical & Substance for Abstract: Blood cells and coagulation during experimental lung insufficiency in dogs. Information

    Substance Name: Fibrinogen

    Registry Number: 9001-32-5

    Grant and Affiliation Information for Blood cells and coagulation during experimental lung insufficiency in dogs.

    AFFILIATION:

    Country: SWEDEN

    SWEDEN Research PublicationSWEDEN Research Publication

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    GRANT:

    ACRONYM:

    MEDLINETA: Acta Chir Scand Suppl

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