Blood-brain barrier damage as a risk factor for corticosteroid-induced psychiatric disorders in systemic lupus erythematosus.

Blood-brain barrier damage as a risk factor for corticosteroid-induced psychiatric disorders in systemic lupus erythematosus. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Blood-brain barrier damage as a risk factor for corticosteroid-induced psychiatric disorders in systemic lupus erythematosus. Abstract Text:

Katsuji Nishimura,Masayoshi Harigai,Masako Omori,Eri Sato,Masako Hara,

To clarify the incidence of and risk factors for corticosteroid-induced psychiatric disorders (CIPDs) in patients with systemic lupus erythematosus (SLE), we conducted a prospective study of 161 consecutive episodes in 155 inpatients with a SLE flare who were treated with corticosteroids. A subgroup of these patients, those who experienced a total of 22 episodes with current overt central nervous system manifestations of SLE (CNS-SLE), were excluded from follow-up. Results of clinical, laboratory, and neurologic tests (including electroencephalography, magnetic resonance imaging of the brain, and cerebrospinal fluid [CSF] analysis), performed within a week before corticosteroid administration, were assessed with regard to development of CIPDs. Within 8 weeks of corticosteroid administration, a diagnosis of CIPD was made for 14 (10.1%) of 139 episodes in 135 patients with a non-CNS-SLE flare. Using multiple logistic regression analysis, we identified positive Q(albumin) (CSF/serum albumin ratio; an indicator of blood-brain barrier [BBB] damage) (odds ratio [OR], 33.3; 95% confidence interval [CI], 3.64-304; p=0.002) and low serum levels of complements (OR, 0.91; 95% CI, 0.83-1.00; p=0.047) as independent risk factors for CIPDs. Positive Q(albumin) was detected in 45% (5 of 11) of episodes in which CIPDs developed. Compared with episodes in which no psychiatric events occurred, a higher level of Q(albumin) was found in episodes in which CIPDs developed, and an even higher level was noted in episodes with active CNS-SLE (Jonckheere-Terpstra test, p<0.001). Although no causal links have been proven, the results from the present study raise the possibility that BBB damage may be associated with SLE- and corticosteroid-induced behavioral changes.

Blood-brain barrier damage as a risk factor for corticosteroid-induced psychiatric disorders in systemic lupus erythematosus. Publishing Authors By Initials

K Nishimura,M Harigai,M Omori,E Sato,M Hara,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Blood-brain barrier damage as a risk factor for corticosteroid-induced psychiatric disorders in systemic lupus erythematosus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Psychoneuroendocrinology

VOLUME: 33

Page Numbers: 395-403

Journal Abbreviation: Psychoneuroendocrinology

ISSN: 0306-4530

DAY: 7

MONTH: 02

YEAR: 2008

Blood-brain barrier damage as a risk factor for corticosteroid-induced psychiatric disorders in systemic lupus erythematosus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7612148

Blood-brain barrier damage as a risk factor for corticosteroid-induced psychiatric disorders in systemic lupus erythematosus. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Blood-brain barrier damage as a risk factor for corticosteroid-induced psychiatric disorders in systemic lupus erythematosus. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Blood-brain barrier damage as a risk factor for corticosteroid-induced psychiatric disorders in systemic lupus erythematosus.

AFFILIATION: Department of Psychiatry, Tokyo Women's Medical University School of Medicine, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Psychoneuroendocrinology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Blood-brain barrier damage as a risk factor for corticosteroid-induced psychiatric disorders in systemic lupus erythematosus Related Publications

• A method to provide magnet-free long straight sections in low-emittance synchrotron radiation sources.
• Absolute calibration of a soft X-ray spectrograph for X-ray laser research using white beam.
• Characteristics of patients with early systemic sclerosis and severe gastrointestinal tract involvement.
• Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.
• Chemical specificity in short-chain fatty acids and their analogues in increasing osmotic fragility in rat erythrocytes in vitro.
• Comparison of 2 contrast materials with different iodine concentrations in 3-dimensional computed tomography angiography of the hepatic artery at multi-detector-row computed tomography: a randomized study.
• Diagnostic reliability of cerebral spinal fluid tests for acute confusional state (delirium) in patients with systemic lupus erythematosus: interleukin 6 (IL-6), IL-8, interferon-alpha, IgG index, and Q-albumin.
• Disruption of CXC motif chemokine ligand-14 in mice ameliorates obesity-induced insulin resistance.
• Ecdysone receptor expression in developing and adult mushroom bodies of the ant Camponotus japonicus.
• Effect of antifungal azoles on the heme detoxification system of malarial parasite.
• Expression of matrix metalloproteinase (MMP) and tissue inhibitor of MMP (TIMP) genes in blasts of infant acute lymphoblastic leukemia with organ involvement.
• Genetic mapping of a food preference gene in the silkworm, Bombyx mori, using restriction fragment length polymorphisms (RFLPs).
• Lig-8, a highly bioactive lignophenol derivative from bamboo lignin, exhibits multifaceted neuroprotective activity.
• Malignant hepatic tumor occurring 10 yrs after a histocompatible sibling donor bone marrow transplantation for severe aplastic anemia.
• Neuroprotective effect of erythropoietin, and role of metallothionein-1 and -2, in permanent focal cerebral ischemia.
• Peptides derived from dolicholin, a phaseolin-like protein in country beans (Dolichos lablab), potently stimulate cholecystokinin secretion from enteroendocrine STC-1 cells.
• Prediction of non-responsiveness to standard high-dose gamma-globulin therapy in patients with acute Kawasaki disease before starting initial treatment.
• Prevention of in vitro and in vivo acute ischemic neuronal damage by (2S)-1-(4-amino-2,3,5-trimethylphenoxy)-3-{4-[4-(4-fluorobenzyl) phenyl]-1-piperazinyl}-2-propanol dimethanesulfonate (SUN N8075), a novel neuroprotective agent with antioxidant properti
• Pyogenic splenic abscess in an infant with serological evidence of cat scratch disease.
• Rifampicin inhibits the retinal neovascularization in vitro and in vivo.
• Serum sulfatides as a novel biomarker for cardiovascular disease in patients with end-stage renal failure.
• Stereoselective Synthesis of (E)- and (Z)-Fluoroalkenylboronates Using 2-Fluoroalkylideneiodonium Ylides Generated from (2-Fluoro-1-alkenyl)iodonium Salts.
• Stereoselective synthesis of 5-7 membered cyclic ethers by deiodonative ring-enlargement using hypervalent iodine reagents.
• Structure-specific effects of thyroxine analogs on human liver 3 alpha-hydroxysteroid dehydrogenase.
• Surgical management of petroclival chordomas: report of eight cases.
• The relationship between retrieval success and task performance during the recognition of meaningless shapes: an event-related near-infrared spectroscopy study.
• Upper cervical spine movement during intubation: fluoroscopic comparison of the AirWay Scope, McCoy laryngoscope, and Macintosh laryngoscope.
• Visualizing the dynamics of p21(Waf1/Cip1) cyclin-dependent kinase inhibitor expression in living animals.
• [Assessment of Biomechanical Characteristic of Denture Supporting Tissue using an Ultrasonic Thickness Gage and a Tactile Sensor.]
• [Changes in Outcome Evaluation before and after Wearing New Complete Dentures.]