Blocking actions of alkylene-tethered bis-neonicotinoids on nicotinic acetylcholine receptors expressed by terminal abdominal ganglion neurons of Periplaneta americana.

Blocking actions of alkylene-tethered bis-neonicotinoids on nicotinic acetylcholine receptors expressed by terminal abdominal ganglion neurons of Periplaneta americana. Research Abstract Details 

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Blocking actions of alkylene-tethered bis-neonicotinoids on nicotinic acetylcholine receptors expressed by terminal abdominal ganglion neurons of Periplaneta americana. Abstract Text:

Makoto Ihara,Koichi Hirata,Chiharu Ishida,Shinzo Kagabu,Kazuhiko Matsuda,Makoto Ihara,Koichi Hirata,Chiharu Ishida,Shinzo Kagabu,Kazuhiko Matsuda,

Neonicotinoid insecticides target nicotinic acetylcholine receptors (nAChRs), which, in both vertebrates and invertebrates, mediate fast-acting synaptic neurotransmission in the nervous system. Recently, Kagabu et al. synthesized bis-neonicotinoids. The neural activities of bis-neonicotinoids have been evaluated on the central nerve cord of American cockroaches. However, the action of bis-neonicotinoids on nAChRs expressed by dissociated insect neurons has not yet been studied. Thus, the actions of several alkylene-tethered bis-neonicotinoids on the terminal abdominal ganglion neurons of the American cockroach, Periplaneta americana, were investigated using whole-cell patch-clamp electrophysiology. All of the ligands tested did not induce membrane currents, but reduced the responses to ACh when bath applied prior to co-application with ACh. Of the compounds tested, HK-13, which possesses two imidacloprid units linked with a hexamethylene bridge, had the highest antagonist potency. The antagonist action was reduced, not only by elongating, but also by shortening the linker.

Blocking actions of alkylene-tethered bis-neonicotinoids on nicotinic acetylcholine receptors expressed by terminal abdominal ganglion neurons of Periplaneta americana. Publishing Authors By Initials

M Ihara,K Hirata,C Ishida,S Kagabu,K Matsuda,M Ihara,K Hirata,C Ishida,S Kagabu,K Matsuda,

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Blocking actions of alkylene-tethered bis-neonicotinoids on nicotinic acetylcholine receptors expressed by terminal abdominal ganglion neurons of Periplaneta americana. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuroscience letters

VOLUME: 425

Page Numbers: 137-40

Journal Abbreviation: Neurosci. Lett.

ISSN: 0304-3940

DAY: 5

MONTH: 07

YEAR: 2007

Blocking actions of alkylene-tethered bis-neonicotinoids on nicotinic acetylcholine receptors expressed by terminal abdominal ganglion neurons of Periplaneta americana. Information

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LANGUAGE: eng

NlmUniqueID: 7600130

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Grant and Affiliation Information for Blocking actions of alkylene-tethered bis-neonicotinoids on nicotinic acetylcholine receptors expressed by terminal abdominal ganglion neurons of Periplaneta americana.

AFFILIATION: Department of Applied Biological Chemistry, School of Agriculture, Kinki University, Nakamachi 3327-204, Nara 631-8505, Japan.

Country: Ireland

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MEDLINETA: Neurosci Lett

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