Blockage of filoviral glycoprotein processing by use of a protein-based inhibitor.

Blockage of filoviral glycoprotein processing by use of a protein-based inhibitor. Research Abstract Details 

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Blockage of filoviral glycoprotein processing by use of a protein-based inhibitor. Abstract Text:

Ute Stroher,Laura Willihnganz,Francois Jean,Heinz Feldmann,Ute ,Laura Willihnganz, Jean,Heinz Feldmann,Ute ,Laura Willihnganz, Jean,Heinz Feldmann,

Cleavage of the glycoproteins of many virus species by furin and other host cell proteases is required for virus infectivity and, hence, determines viral pathogenicity. Proteolytic processing of Marburg virus and Ebola virus glycoproteins is also mediated by furin; however, for Ebola virus, in contrast to other viruses, glycoprotein cleavage is dispensable for replication in vitro, as has been shown in previous studies. In the present study, by use of a highly potent and selective furin inhibitor, we demonstrate that glycoprotein cleavage inhibition results in a minimal reduction in the virus titer that is insufficient to block filoviral replication. Thus, furin inhibitors are unlikely to be effective in the treatment of filoviral infections.

Blockage of filoviral glycoprotein processing by use of a protein-based inhibitor. Publishing Authors By Initials

U Stroher,L Willihnganz,F Jean,H Feldmann,U ,L Willihnganz,F Jean,H Feldmann,U ,L Willihnganz,F Jean,H Feldmann,

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Blockage of filoviral glycoprotein processing by use of a protein-based inhibitor. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of infectious diseases

VOLUME: 196 Suppl 2

Page Numbers: S271-5

Journal Abbreviation: J. Infect. Dis.

ISSN: 0022-1899

DAY: 15

MONTH: Nov

YEAR: 2007

Blockage of filoviral glycoprotein processing by use of a protein-based inhibitor. Information

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LANGUAGE: eng

NlmUniqueID: 413675

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Grant and Affiliation Information for Blockage of filoviral glycoprotein processing by use of a protein-based inhibitor.

AFFILIATION: Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Manitoba, R3E 3R2, Canada. Ute_Stroeher@phac-aspc.gc.ca.

Country: United States

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MEDLINETA: J Infect Dis

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