BLM helicase-dependent and -independent roles of 53BP1 during replication stress-mediated homologous recombination.

BLM helicase-dependent and -independent roles of 53BP1 during replication stress-mediated homologous recombination. Research Abstract Details 

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BLM helicase-dependent and -independent roles of 53BP1 during replication stress-mediated homologous recombination. Abstract Text:

Vivek Tripathi,Tirunelvely Nagarjuna,Sagar Sengupta,

Mutations in BLM helicase cause Bloom syndrome, characterized by predisposition to all forms of cancer. We demonstrate that BLM, signal transducer 53BP1, and RAD51 interact during stalled replication. Interactions between the three proteins have functional consequences. Lack of 53BP1 decreases the cell survival and enhanced chromosomal aberration after replication arrest. 53BP1 exhibits both BLM-dependent and -independent anti-recombinogenic functions in human and mouse cells. Both BLM and 53BP1 abrogate endogenous RAD51 foci formation and disrupt RAD51 polymerization. Consequently, loss of BLM and 53BP1 synergistically enhances stress-dependent homologous recombination. These results provide evidence regarding the cooperation between BLM and 53BP1 during maintenance of genomic integrity.

BLM helicase-dependent and -independent roles of 53BP1 during replication stress-mediated homologous recombination. Publishing Authors By Initials

V Tripathi,T Nagarjuna,S Sengupta,

For similar investigative techniques: genetic techniques: gene transfer techniques: transfection research abstracts see: investigative techniques: genetic techniques: gene transfer techniques: transfection research

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BLM helicase-dependent and -independent roles of 53BP1 during replication stress-mediated homologous recombination. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of cell biology

VOLUME: 178

Page Numbers: 9-14

Journal Abbreviation: J. Cell Biol.

ISSN: 0021-9525

DAY: 25

MONTH: 06

YEAR: 2007

BLM helicase-dependent and -independent roles of 53BP1 during replication stress-mediated homologous recombination. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375356

BLM helicase-dependent and -independent roles of 53BP1 during replication stress-mediated homologous recombination. Keywords Mesh Terms:

KEYWORDS: Transfection

MESH TERMS: genetics

Chemical & Substance for Abstract: BLM helicase-dependent and -independent roles of 53BP1 during replication stress-mediated homologous recombination. Information

Substance Name: DNA Helicases

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for BLM helicase-dependent and -independent roles of 53BP1 during replication stress-mediated homologous recombination.

AFFILIATION: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India.

Country: United States

AGENCY: United States FIC

GRANT: 1 R01 TW0073202-01A1

ACRONYM: TW

MEDLINETA: J Cell Biol

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