Blastocyst-derived trophoblast stem cells from the rhesus monkey.

Blastocyst-derived trophoblast stem cells from the rhesus monkey. Research Abstract Details 

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Blastocyst-derived trophoblast stem cells from the rhesus monkey. Abstract Text:

Catherine A Vandevoort,Twanda L Thirkill,Gordon C Douglas,Catherine A Vandevoort,Twanda L Thirkill,Gordon C Douglas,Catherine A Vandevoort,Twanda L Thirkill,Gordon C Douglas,

Although trophoblast stem cells can be obtained directly from blastocyst outgrowths in the mouse, this has never been described in primates. In human and non-human primates, trophoblast cells have been obtained from embryonic stem (ES) cells or embryoid bodies (EBs). The results reported here show for the first time that cells with the characteristics of trophoblast stem cells can be derived directly from rhesus monkey blastocyst outgrowths. The cells expressed trophoblast markers and were maintained for multiple passages in the absence of feeder layers or growth factors. The cells could be maintained as adherent, mononuclear cells by regular passaging, but they formed syncytial-like structures if maintained in culture for prolonged periods or if incubated in the presence of 17beta-estradiol. The cells also demonstrated invasive behavior similar to extravillous trophoblasts. The availability of these lines provides a useful experimental system for studying trophoblast differentiation and for developing novel intervention strategies to treat placental dysfunction.

Blastocyst-derived trophoblast stem cells from the rhesus monkey. Publishing Authors By Initials

CA Vandevoort,TL Thirkill,GC Douglas,CA Vandevoort,TL Thirkill,GC Douglas,CA Vandevoort,TL Thirkill,GC Douglas,

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Blastocyst-derived trophoblast stem cells from the rhesus monkey. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Stem cells and development

VOLUME: 16

Page Numbers: 779-88

Journal Abbreviation: Stem Cells Dev.

ISSN: 1547-3287

DAY: 16

MONTH: Oct

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Blastocyst-derived trophoblast stem cells from the rhesus monkey.

AFFILIATION: California National Primate Research Center, Department of Obstetrics and Gynecology, School of Medicine, University of California, Davis CA 95616.

Country: United States

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MEDLINETA: Stem Cells Dev

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