Bladder inhibition or voiding induced by pudendal nerve stimulation in chronic spinal cord injured cats.

Bladder inhibition or voiding induced by pudendal nerve stimulation in chronic spinal cord injured cats. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Bladder inhibition or voiding induced by pudendal nerve stimulation in chronic spinal cord injured cats. Abstract Text:

Changfeng Tai,Jicheng Wang,Xianchun Wang,William C de Groat,James R Roppolo,

AIMS: To investigate pudendal-to-bladder spinal reflexes in chronic spinal cord injured (SCI) cats induced by electrical stimulation of the pudendal nerve. METHODS: Bladder inhibition or voiding induced by pudendal nerve stimulation at different frequencies (3 or 20 Hz) was studied in three female, chronic SCI cats under alpha-chloralose anesthesia. RESULTS: Voiding induced by a slow infusion (2-4 ml/min) of saline into the bladder was very inefficient (voiding efficiency=7.3%+/-0.9%). Pudendal nerve stimulation at 3 Hz applied during the slow infusion inhibited reflex bladder activity, and significantly increased bladder capacity to 147.2+/-6.1% of its control capacity. When the 3-Hz stimulation was terminated, voiding rapidly occurred and the voiding efficiency was increased to 25.4+/-6.1%, but residual bladder volume was not reduced. Pudendal nerve stimulation at 20 Hz induced large bladder contractions, but failed to induce voiding during the stimulation due to the direct activation of the motor pathway to the external urethral sphincter. However, intermittent pudendal nerve stimulation at 20 Hz induced post-stimulus voiding with 78.3+/-12.1% voiding efficiency. The voiding pressures (39.3+/-6.2 cmH2O) induced by the intermittent pudendal nerve stimulation were higher than the voiding pressures (23.1+/-1.7 cmH2O) induced by bladder distension. The flow rate during post-stimulus voiding induced by the intermittent pudendal nerve stimulation was significantly higher (0.93+/-0.04 ml/sec) than during voiding induced by bladder distension (0.23+/-0.07 ml/sec). CONCLUSIONS: This study indicates that a neural prosthetic device based on pudendal nerve stimulation might be developed to restore micturition function for people with SCI.

Bladder inhibition or voiding induced by pudendal nerve stimulation in chronic spinal cord injured cats. Publishing Authors By Initials

C Tai,J Wang,X Wang,WC de Groat,JR Roppolo,

For similar reproductive and urinary physiology: urinary tract physiology: urination research abstracts see: reproductive and urinary physiology: urinary tract physiology: urination research

PUBMED ID PMID:

MEDLINE DATE:

Bladder inhibition or voiding induced by pudendal nerve stimulation in chronic spinal cord injured cats. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neurourology and urodynamics

VOLUME: 26

Page Numbers: 570-7

Journal Abbreviation: Neurourol. Urodyn.

ISSN: 0733-2467

DAY: 3

MONTH: 12

YEAR: 2007

Bladder inhibition or voiding induced by pudendal nerve stimulation in chronic spinal cord injured cats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8303326

Bladder inhibition or voiding induced by pudendal nerve stimulation in chronic spinal cord injured cats. Keywords Mesh Terms:

KEYWORDS: Urination

MESH TERMS: physiology

Chemical & Substance for Abstract: Bladder inhibition or voiding induced by pudendal nerve stimulation in chronic spinal cord injured cats. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Bladder inhibition or voiding induced by pudendal nerve stimulation in chronic spinal cord injured cats.

AFFILIATION: Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. cftai@pitt.edu

Country: United States

AGENCY: United States NIDDK

GRANT: 1R01-DK-068566-01

ACRONYM: DK

MEDLINETA: Neurourol Urodyn

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Bladder inhibition or voiding induced by pudendal nerve stimulation in chronic spinal cord injured cats Related Publications

• Bladder inhibition or voiding induced by pudendal nerve stimulation in chronic spinal cord injured cats.
• Cerebellar venous angioma: "benign" entity?