Bladder and urethral function in pelvic organ prolapsed lysyl oxidase like-1 knockout mice.

Bladder and urethral function in pelvic organ prolapsed lysyl oxidase like-1 knockout mice. Research Abstract Details 

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Bladder and urethral function in pelvic organ prolapsed lysyl oxidase like-1 knockout mice. Abstract Text:

Guiming Liu,Firouz Daneshgari,Mei Li,Danli Lin,Una Lee,Tiansen Li,Margot S Damaser,

OBJECTIVES: To examine bladder and urethral function in pelvic organ prolapsed lysyl oxidase like-1 (LOXL1) knockout mice. MATERIALS AND METHODS: Female parous Loxl1 (-/-) mice in the stable phase of prolapse, and age-matched wild type (WT) mice (six each) had conscious cystometry, leak-point pressure (LPP) testing, and contractile responses assessed of their bladder muscle strips to KCl, electrical-field stimulation, ATP, and carbachol. RESULTS: Loxl1 (-/-) mice voided more frequently and had lower mean (sem) bladder capacity, at 0.10 (0.01) vs 0.20 (0.01) mL, and voiding pressure, at 25.0 (1.90) vs 36.6 (4.04) cmH(2)O, respectively, during cystometry than had WT mice. The LPP was not significantly different between WT and Loxl1 (-/-) mice, at 7.05 (0.81) vs 5.22 (1.23) cmH(2)O, respectively. There were no significant differences between bladder strips from Loxl1 (-/-) mice and WT mice in their responsiveness to various stimuli. CONCLUSIONS: Loxl1 (-/-) knockout mice had lower urinary tract dysfunction, most likely due to urethral dysfunction. Loxl1 (-/-) knockout mice can be used as an animal model for pelvic floor disorders. Further studies are needed to characterize the morphological and molecular alterations of the bladder and urethra.

Bladder and urethral function in pelvic organ prolapsed lysyl oxidase like-1 knockout mice. Publishing Authors By Initials

G Liu,F Daneshgari,M Li,D Lin,U Lee,T Li,MS Damaser,

For similar female urogenital diseases and pregnancy complications: female urogenital diseases: genital diseases, female: uterine diseases: uterine prolapse research abstracts see: female urogenital diseases and pregnancy complications: female urogenital diseases: genital diseases, female: uterine diseases: uterine prolapse research

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MEDLINE DATE:

Bladder and urethral function in pelvic organ prolapsed lysyl oxidase like-1 knockout mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: BJU international

VOLUME: 100

Page Numbers: 414-8

Journal Abbreviation: BJU Int.

ISSN: 1464-4096

DAY: 6

MONTH: 06

YEAR: 2007

Bladder and urethral function in pelvic organ prolapsed lysyl oxidase like-1 knockout mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100886721

Bladder and urethral function in pelvic organ prolapsed lysyl oxidase like-1 knockout mice. Keywords Mesh Terms:

KEYWORDS: Uterine Prolapse

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Bladder and urethral function in pelvic organ prolapsed lysyl oxidase like-1 knockout mice. Information

Substance Name: Loxl1 protein, mouse

Registry Number: EC 1.4.3.-

Grant and Affiliation Information for Bladder and urethral function in pelvic organ prolapsed lysyl oxidase like-1 knockout mice.

AFFILIATION: Glickman Urological Institute & Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH 44195, USA.

Country: England

AGENCY: United States NIDDK

GRANT: KO8 DK02631

ACRONYM: DK

MEDLINETA: BJU Int

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