Birthweight and body size throughout life in relation to sex hormones and prolactin concentrations in premenopausal women.

Birthweight and body size throughout life in relation to sex hormones and prolactin concentrations in premenopausal women. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Birthweight and body size throughout life in relation to sex hormones and prolactin concentrations in premenopausal women. Abstract Text:

Shelley S Tworoger,A Heather Eliassen,Stacey A Missmer,Heather Baer,Janet Rich-Edwards,Karin B Michels,Robert L Barbieri,Mitch Dowsett,Susan E Hankinson,

The association of birthweight and body size throughout life with premenopausal breast cancer risk may be due, in part, to relationships with sex hormones. Therefore, we assessed whether birthweight, body shape at ages 5 and 10, body mass index (BMI) at age 18 and adulthood, adult waist circumference and waist-to-hip ratio (WHR), and attained height were associated with the plasma concentrations of estrogens, androgens, progesterone, prolactin, and sex hormone-binding globulin (SHBG) in 592 premenopausal women, ages 33 to 52 years old, from the Nurses' Health Study II. About 85% of women provided blood samples during follicular and luteal menstrual phases; other women had a single untimed sample. We observed few associations between sex hormone levels and birthweight or body shape in childhood. However, adult BMI was inversely associated with SHBG (P trend < 0.001) and positively associated with free testosterone (P trend < 0.001) concentrations. Adult BMI was not associated with follicular or luteal free estradiol levels (P trend >or= 0.15) because it was inversely associated with total estradiol levels (P trend < 0.001 for follicular and luteal estradiol levels). Testosterone, androstenedione, and progesterone were inversely associated with BMI. Comparing women with a BMI of >or=30 versus <20 kg/m2, levels were higher by 53% for free testosterone and lower by 51% for SHBG, 39% for follicular estradiol, 20% for luteal estradiol, 14% for androstenedione, 13% for testosterone, and 20% for progesterone. We observed no clear associations between BMI at age 18, waist circumference, WHR, or height, and sex hormone concentrations. Our results suggest that effects on premenopausal sex hormone levels may be one mechanism through which adult adiposity, but not birthweight or childhood body size, affects premenopausal breast cancer risk.

Birthweight and body size throughout life in relation to sex hormones and prolactin concentrations in premenopausal women. Publishing Authors By Initials

SS Tworoger,AH Eliassen,SA Missmer,H Baer,J Rich-Edwards,KB Michels,RL Barbieri,M Dowsett,SE Hankinson,

For similar diagnosis: diagnostic techniques and procedures: physical examination: body constitution: body weights and measures: waist-hip ratio research abstracts see: diagnosis: diagnostic techniques and procedures: physical examination: body constitution: body weights and measures: waist-hip ratio research

PUBMED ID PMID:

MEDLINE DATE:

Birthweight and body size throughout life in relation to sex hormones and prolactin concentrations in premenopausal women. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer epidemiology, biomarkers & prevention : a p

VOLUME: 15

Page Numbers: 2494-501

Journal Abbreviation: Cancer Epidemiol. Biomarkers P

ISSN: 1055-9965

DAY: 3

MONTH: Dec

YEAR: 2006

Birthweight and body size throughout life in relation to sex hormones and prolactin concentrations in premenopausal women. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9200608

Birthweight and body size throughout life in relation to sex hormones and prolactin concentrations in premenopausal women. Keywords Mesh Terms:

KEYWORDS: Waist-Hip Ratio

MESH TERMS: blood

Chemical & Substance for Abstract: Birthweight and body size throughout life in relation to sex hormones and prolactin concentrations in premenopausal women. Information

Substance Name: Prolactin

Registry Number: 9002-62-4

Grant and Affiliation Information for Birthweight and body size throughout life in relation to sex hormones and prolactin concentrations in premenopausal women.

AFFILIATION: Channing Laboratory, 181 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA. nhsst@channing.harvard.edu

Country: United States

AGENCY: United States NCI

GRANT: R25 CA 098566-2

ACRONYM: CA

MEDLINETA: Cancer Epidemiol Biomarkers Pr

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Birthweight and body size throughout life in relation to sex hormones and prolactin concentrations in premenopausal women Related Publications

• A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P4502S1 by both dioxin and hypoxia.
• A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer.
• A prospective study of plasma prolactin concentrations and risk of premenopausal and postmenopausal breast cancer.
• A prospective study of postmenopausal hormone use and ovarian cancer risk.
• Aspirin, NSAID, and Acetaminophen Use and the Risk of Endometrial Cancer.
• Association of activity and chronic disease risk factors: utility and limitations of objectively measured physical activity data.
• Association of oral contraceptive use, other contraceptive methods, and infertility with ovarian cancer risk.
• Birthweight and body size throughout life in relation to sex hormones and prolactin concentrations in premenopausal women.
• Body shape throughout life and correlations with IGFs and GH.
• Breastfeeding and risk of ovarian cancer in two prospective cohorts.
• Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer.
• Circulating colony stimulating factor-1 and breast cancer risk.
• Circulating insulin and c-peptide levels and risk of breast cancer among predominately premenopausal women.
• Circulating levels of sex steroids and prolactin in premenopausal women and risk of breast cancer.
• Dietary patterns, the Alternate Healthy Eating Index and plasma sex hormone concentrations in postmenopausal women.
• Endogenous hormone levels, mammographic density, and subsequent risk of breast cancer in postmenopausal women.
• Identification of novel dioxin-responsive genes by representational difference analysis.
• Identifying target genes of the aryl hydrocarbon receptor nuclear translocator (Arnt) using DNA microarray analysis.
• Insulin-like growth factors and ovarian cancer risk: a nested case-control study in three cohorts.
• Menopausal and reproductive factors and risk of age-related macular degeneration.
• Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones.
• Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of incident ovarian cancer.
• Plasma adiponectin concentrations and risk of incident breast cancer.
• Plasma androgen concentrations and risk of incident ovarian cancer.
• Prolactin and breast cancer risk.
• Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels.
• Reproducibility of proteomic profiles over 3 years in postmenopausal women not taking postmenopausal hormones.
• The role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon receptor action.
• Use of biomarkers in epidemiologic studies: minimizing the influence of measurement error in the study design and analysis.
• Why does ARNT2 behave differently from ARNT?