Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers.

Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers. Research Abstract Details 

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Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers. Abstract Text:

BACKGROUND: New research is dramatically altering our understanding of the molecular mechanisms underlying neuronal communication. AIM: To elucidate the molecular mechanisms underlying the therapeutic effects of mood stabilizers. METHOD: Results from integrated clinical and laboratory studies are reviewed. RESULTS: Chronic administration of lithium and valproate produced a striking reduction in protein kinase C (PKC) isozymes in rat frontal cortex and hippocampus. In a small study, tamoxifen (also a PKC inhibitor) had marked antimanic efficacy. Both lithium and valproate regulate the DNA binding activity of the activator protein I family of transcription factors. Using mRNA differential display, it was also shown that chronic administration of lithium and valproate modulates expression of several genes. An exciting finding is that of a robust elevation in the levels of the cytoprotective protein, bcl-2. CONCLUSIONS: The results suggest that regulation of signalling pathways may play a major part in the long-term actions of mood stabilizers. Additionally, mood stabilizers may exert underappreciated neuroprotective effects.

Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers. Publishing Authors By Initials

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers. Journal Published:

PUBLICATION TYPE: Review

Journal: The British journal of psychiatry. Supplement

VOLUME: 41

Page Numbers: s107-19

Journal Abbreviation:

ISSN: 0960-5371

DAY: 22

MONTH: Jun

YEAR: 2001

Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers. Information

Number of References: 141

LANGUAGE: eng

NlmUniqueID: 9001294

Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: drug effects

Chemical & Substance for Abstract: Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers. Information

Substance Name: Calcium-Calmodulin-Dependent Protein Kin

Registry Number: EC 2.7.11.17

Grant and Affiliation Information for Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers.

AFFILIATION: Laboratory of Molecular Pathophysiology, Wayne State University School of Medicine, Detroit, Michigan, USA. manjih@intra.nimh.nih.gov

Country: England

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MEDLINETA: Br J Psychiatry Suppl

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