Biotransformation of myrislignan by rat liver microsomes in vitro.

Biotransformation of myrislignan by rat liver microsomes in vitro. Research Abstract Details 

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Biotransformation of myrislignan by rat liver microsomes in vitro. Abstract Text:

Fei Li,Xiu-Wei Yang,

Myrislignan (1), erythro-(1R,2S)-2-(4-allyl-2,6-dimethoxyphenoxyl)-1-(4-hydroxy-3-methoxyphenyl) propan-1-ol, is a major acyclic neolignan in seeds of Myristica fragrans. Studies have suggested that myrislignan may deter feeding activity, but little is known about its metabolism. We investigated the biotransformation of myrislignan by rat liver microsomes in vitro. Seven metabolites were produced by liver microsomes from rats pre-treated with sodium phenobarbital. These were identified, using spectroscopic methods, as myrislignanometins A-G (2-8), respectively.

Biotransformation of myrislignan by rat liver microsomes in vitro. Publishing Authors By Initials

F Li,XW Yang,

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Biotransformation of myrislignan by rat liver microsomes in vitro. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Phytochemistry

VOLUME: 69

Page Numbers: 765-71

Journal Abbreviation: Phytochemistry

ISSN: 0031-9422

DAY: 26

MONTH: 10

YEAR: 2007

Biotransformation of myrislignan by rat liver microsomes in vitro. Information

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LANGUAGE: eng

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AFFILIATION: The State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China.

Country: United States

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MEDLINETA: Phytochemistry

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