Biotransformation of maximakinin, a bradykinin-related nonadecapeptide from toad venom, by mammalian kallikrein and salivary proteases.

Biotransformation of maximakinin, a bradykinin-related nonadecapeptide from toad venom, by mammalian kallikrein and salivary proteases. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Biotransformation of maximakinin, a bradykinin-related nonadecapeptide from toad venom, by mammalian kallikrein and salivary proteases. Abstract Text:

T Chen,M O'rourke,J McKenna,D G Hirst,C Shaw,

Maximakinin is an N-terminally extended bradykinin (DLPKINRKGPRPPGFSPFR) from the venom of a Chinese toad (Bombina maxima) that displays highly selective activity at mammalian arterial smooth muscle receptors. In this study, we report that incubation of maximakinin with either kallikrein or human saliva generates catabolites with enhanced bioactivity that retain the tissue selective effects of the parent molecule. In addition, we have observed that kallikrein rapidly cleaves the C-terminal arginyl residue of both maximakinin and bradykinin - a cleavage hitherto considered to be performed by a carboxypeptidase that facilitates selective bradykinin receptor targeting. Maximakinin has thus evolved as a 'smart' defensive weapon in the toad with inherent resistance to the signal-terminating protease hardware in the potential predator. Thus, natural selection of amphibian skin peptides for antipredator defence, through interspecies delivery by an exogenous secretory mode, produces subtle structural stabilization modifications that can potentially provide new insights for the design of orally active and selectively targeted peptide therapeutics.

Biotransformation of maximakinin, a bradykinin-related nonadecapeptide from toad venom, by mammalian kallikrein and salivary proteases. Publishing Authors By Initials

T Chen,M O'rourke,J McKenna,DG Hirst,C Shaw,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Biotransformation of maximakinin, a bradykinin-related nonadecapeptide from toad venom, by mammalian kallikrein and salivary proteases. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The journal of peptide research : official journal

VOLUME: 66 Suppl 1

Page Numbers: 106-13

Journal Abbreviation: J. Pept. Res.

ISSN: 1397-002X

DAY: 2

MONTH: Dec

YEAR: 2005

Biotransformation of maximakinin, a bradykinin-related nonadecapeptide from toad venom, by mammalian kallikrein and salivary proteases. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9707067

Biotransformation of maximakinin, a bradykinin-related nonadecapeptide from toad venom, by mammalian kallikrein and salivary proteases. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Biotransformation of maximakinin, a bradykinin-related nonadecapeptide from toad venom, by mammalian kallikrein and salivary proteases. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Biotransformation of maximakinin, a bradykinin-related nonadecapeptide from toad venom, by mammalian kallikrein and salivary proteases.

AFFILIATION: School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, UK.

Country: Denmark

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Pept Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Biotransformation of maximakinin, a bradykinin-related nonadecapeptide from toad venom, by mammalian kallikrein and salivary proteases Related Publications

• A cricket Gene Index: a genomic resource for studying neurobiology, speciation, and molecular evolution.
• Age-associated defect in human TLR-1/2 function.
• Aluminum adjuvant linked to gulf war illness induces motor neuron death in mice.
• Biotransformation of maximakinin, a bradykinin-related nonadecapeptide from toad venom, by mammalian kallikrein and salivary proteases.
• Community exposure to perfluorooctanoate: relationships between serum concentrations and exposure sources.
• Community exposure to perfluorooctanoate: relationships between serum levels and certain health parameters.
• Ct05 mechanical valve or tissue valve: do patients regret their decision?
• Ct23 what's new in ICU.
• Ct25 cpap: an overview and current applications.
• Ct27 a history of errors and the christchurch solution.
• Ct32 when to call the surgeon.
• Developmental divergence of sleep-wake patterns in orexin knockout and wild-type mice.
• Do the predictors of child conduct problems vary by high- and low-levels of socioeconomic and neighborhood risk?
• Ending the splits.
• Essentials of sleep recordings in Drosophila: moving beyond sleep time.
• From Sydney to Athens: preparing for the Olympic and Paralympic Games.
• Identification of a biomarker for sleep drive in flies and humans.
• Impact of neighborhood disadvantage on overt behavior problems during early childhood.
• Leptin predicts the development of diabetes in Mauritian men, but not women: a population-based study.
• Mitochondrial DNA haplogroups and amyotrophic lateral sclerosis.
• Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults.
• Six year incidence and progression of diabetic retinopathy: results from the Mauritius diabetes complication study.
• Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.
• Synthesis and stereochemical assignment of brasilibactin A.
• Synthesis of kaempferitrin.
• Testing mediators of intervention effects in randomized controlled trials: An evaluation of two eating disorder prevention programs.
• The African orphan crisis and international adoption.
• The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse.
• Ugo1p is a multipass transmembrane protein with a single carrier domain required for mitochondrial fusion.
• [The self-training of a therapist : a demystification process.]