Biotransformation of diosgenin to nuatigenin-type steroid by a newly isolated strain, Streptomyces virginiae IBL-14.

Biotransformation of diosgenin to nuatigenin-type steroid by a newly isolated strain, Streptomyces virginiae IBL-14. Research Abstract Details 

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Biotransformation of diosgenin to nuatigenin-type steroid by a newly isolated strain, Streptomyces virginiae IBL-14. Abstract Text:

Feng-Qing Wang,Bo Li,Wei Wang,Cheng-Gang Zhang,Dong-Zhi Wei,Feng-Qing Wang,Bo Li,Wei Wang,Cheng-Gang Zhang,Dong-Zhi Wei,Feng-Qing Wang,Bo Li,Wei Wang,Cheng-Gang Zhang,Dong-Zhi Wei,

An actinomycete strain IBL-14 isolated from soil by utilizing diosgenin as the sole carbon and energy source was identified as Streptomyces virginiae. S. virginiae IBL-14 can transform diosgenin to isonuatigenone. To our knowledge, this is the first reported case of producing rare nuatigenin-type spirosteroid (isonuatigenone) from pyrano-spirosteroid (diosgenin) by microbial transformation. From diosgenin to isonuatigenone, the pathway has been confirmed in this study that diosgenin was first converted to diosgenone, and then diosgenone was transformed to isonuatigenone by the C25 tertiary hydroxylation reaction. It appeared to be favorable to accumulate isonuatigenone when diosgenin was added to the onset of the stationary phase of cell growth, and the yield of isonuatigenone was about 28.4% during 48 h from 1.5 mM diosgenin. The C25 tertiary hydroxylation of diosgenone by S. virginiae IBL-14 is a novel and interesting reaction and will be a practical tool in producing natural nuatigenin-type steroids.

Biotransformation of diosgenin to nuatigenin-type steroid by a newly isolated strain, Streptomyces virginiae IBL-14. Publishing Authors By Initials

FQ Wang,B Li,W Wang,CG Zhang,DZ Wei,FQ Wang,B Li,W Wang,CG Zhang,DZ Wei,FQ Wang,B Li,W Wang,CG Zhang,DZ Wei,

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Biotransformation of diosgenin to nuatigenin-type steroid by a newly isolated strain, Streptomyces virginiae IBL-14. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Applied microbiology and biotechnology

VOLUME: 77

Page Numbers: 771-7

Journal Abbreviation: Appl. Microbiol. Biotechnol.

ISSN: 0175-7598

DAY: 23

MONTH: 10

YEAR: 2007

Biotransformation of diosgenin to nuatigenin-type steroid by a newly isolated strain, Streptomyces virginiae IBL-14. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Biotransformation of diosgenin to nuatigenin-type steroid by a newly isolated strain, Streptomyces virginiae IBL-14.

AFFILIATION: State Key Laboratory of Bioreactor Engineering, Newworld Institute of Biotechnology, East China University of Science and Technology, P.O. Box 311, Shanghai, 200237, China, dzhwei@ecust.edu.cn.

Country: Germany

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MEDLINETA: Appl Microbiol Biotechnol

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