Biotechnological approaches to the production of idiotypic vaccines and antiidiotypic antibiotics.

Biotechnological approaches to the production of idiotypic vaccines and antiidiotypic antibiotics. Research Abstract Details 

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Biotechnological approaches to the production of idiotypic vaccines and antiidiotypic antibiotics. Abstract Text:

The potential therapeutic activity of a killer toxin produced by the yeast Pichia anomala (PaKT) characterized by its wide spectrum of antimicrobial activity has been exploited through the simulation of its interaction with the specific cell wall receptor (KTR) of PaKT-sensitive microorganisms by the idiotypic network. Killer antiidiotypes (PaKTantiId) produced by idiotypic vaccination with a PaKT-neutralizing monoclonal antibody have proven to confer active and passive immunoprotection in experimental models of systemic and vaginal candidiasis. PaKTantiId-like human anti-KTR antibodies are naturally produced in infections caused by PaKT-sensitive microorganisms. PaKTantiId in its monoclonal and recombinant formats as well as expressed on human commensal bacteria have shown microbicidal activity in vitro and a therapeutic effect in experimental models of infection caused by PaKT-sensitive microorganisms. New perspectives of idiotypic vaccination and antiidiotypic antibiotic therapy and biotechnological approaches to the production of trandisease idiotypic vaccines and wide-spectrum antiidiotypic antibiotics (killer mimotopes) will be discussed as effective tools to fight epidemiologically important mucosal and systemic microbial infections.

Biotechnological approaches to the production of idiotypic vaccines and antiidiotypic antibiotics. Publishing Authors By Initials

For similar investigative techniques: technology, pharmaceutical research abstracts see: investigative techniques: technology, pharmaceutical research

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Biotechnological approaches to the production of idiotypic vaccines and antiidiotypic antibiotics. Journal Published:

PUBLICATION TYPE: Review

Journal: Current pharmaceutical biotechnology

VOLUME: 4

Page Numbers: 91-7

Journal Abbreviation: Curr Pharm Biotechnol

ISSN: 1389-2010

DAY: 12

MONTH: Apr

YEAR: 2003

Biotechnological approaches to the production of idiotypic vaccines and antiidiotypic antibiotics. Information

Number of References: 59

LANGUAGE: eng

NlmUniqueID: 100960530

Biotechnological approaches to the production of idiotypic vaccines and antiidiotypic antibiotics. Keywords Mesh Terms:

KEYWORDS: Technology, Pharmaceutical

MESH TERMS: methods

Chemical & Substance for Abstract: Biotechnological approaches to the production of idiotypic vaccines and antiidiotypic antibiotics. Information

Substance Name: Immunoglobulin Idiotypes

Registry Number: 0

Grant and Affiliation Information for Biotechnological approaches to the production of idiotypic vaccines and antiidiotypic antibiotics.

AFFILIATION: Dipartimento di Patologia e Medicina di Laboratorio, Università degli Studi di Parma, Viale Antonio Gramsci 14, 43100 Parma, Italy. magliwal@unipr.it

Country: Netherlands

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MEDLINETA: Curr Pharm Biotechnol

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