Biosynthesis of prostaglandins in human allergic contact dermatitis.

Biosynthesis of prostaglandins in human allergic contact dermatitis. Research Abstract Details 

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Biosynthesis of prostaglandins in human allergic contact dermatitis. Abstract Text:

The biosynthesis of prostaglandins by human inflamed skin was studied in 5 patients with allergic contact dermatitis induced by patch tests. Inflamed skin from these patients evidenced an increased ability to synthesize prostaglandins. In the presence of exogenous arachidonic acid in the incubation medium, the activity formed was about 60% greater in inflamed skin than in noninflamed control skin. In prostaglandin E1-equivalents the concentration amounted to 9.19 +/- 2.02 ng/mg protein nitrogen and 5.74 +/- 1.97 ng/mg protein nitrogen, respectively (mean values +/- S.E.). When inflamed skin was incubated without excess of exogenous precursor acids in the incubation medium the activity formed was about 130 times lower and the values were similar to those of non-inflamed skin. Thus, the present results support the view that the prostaglandin system is activated in allergic contact dermatitis, thereby providing a basis for future therapeutic attempts to control this disorder.

Biosynthesis of prostaglandins in human allergic contact dermatitis. Publishing Authors By Initials

For similar integumentary system: skin research abstracts see: integumentary system: skin research

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Biosynthesis of prostaglandins in human allergic contact dermatitis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives for dermatological research. Archiv für d

VOLUME: 257

Page Numbers: 143-7

Journal Abbreviation:

ISSN: 0340-3696

DAY: 15

MONTH: Dec

YEAR: 1976

Biosynthesis of prostaglandins in human allergic contact dermatitis. Information

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LANGUAGE: eng

NlmUniqueID: 7512589

Biosynthesis of prostaglandins in human allergic contact dermatitis. Keywords Mesh Terms:

KEYWORDS: Skin

MESH TERMS: metabolism

Chemical & Substance for Abstract: Biosynthesis of prostaglandins in human allergic contact dermatitis. Information

Substance Name: Prostaglandins

Registry Number: 0

Grant and Affiliation Information for Biosynthesis of prostaglandins in human allergic contact dermatitis.

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Country: GERMANY, WEST

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MEDLINETA: Arch Dermatol Res

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