Bioprosthetic heart valve heterograft biomaterials: structure, mechanical behavior and computational simulation.

Bioprosthetic heart valve heterograft biomaterials: structure, mechanical behavior and computational simulation. Research Abstract Details 

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Bioprosthetic heart valve heterograft biomaterials: structure, mechanical behavior and computational simulation. Abstract Text:

Michael S Sacks,Ali Mirnajafi,Wei Sun,Paul Schmidt,

The present review surveys significant developments in the biomechanical characterization and computational simulation of biologically derived chemically cross-linked soft tissues, or 'heterograft' biomaterials, used in replacement bioprosthetic heart valve (BHV). A survey of mechanical characterization techniques, relevant mechanical properties and computational simulation approaches is presented for both the source tissues and cross-linked biomaterials. Since durability remains the critical problem with current bioprostheses, changes with the mechanical behavior with fatigue are also presented. Moreover, given the complex nature of the mechanical properties of heterograft biomaterials it is not surprising that most constitutive (stress-strain) models, historically used to characterize their behavior, were oversimplified. Simulations of BHV function utilizing these models have inevitably been inaccurate. Thus, more recent finite element simulations utilizing nonlinear constitutive models, which achieve greater model fidelity, are reviewed. An important conclusion of this review is the need for accurate constitutive models, rigorously validated with appropriate experimental data, in order that the design benefits of computational models can be realized. Finally, for at least the coming 20 years, BHVs fabricated from heterograft biomaterials will continue to be extensively used, and will probably remain as the dominant valve design. We should thus recognize that rational, scientifically based approaches to BHV biomaterial development and design can lead to significantly improved BHV, over the coming decades, which can potentially impact millions of patients worldwide with heart valve disease.

Bioprosthetic heart valve heterograft biomaterials: structure, mechanical behavior and computational simulation. Publishing Authors By Initials

MS Sacks,A Mirnajafi,W Sun,P Schmidt,

For similar surgical procedures, operative: transplantation: transplantation, heterologous research abstracts see: surgical procedures, operative: transplantation: transplantation, heterologous research

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Bioprosthetic heart valve heterograft biomaterials: structure, mechanical behavior and computational simulation. Journal Published:

PUBLICATION TYPE: Review

Journal: Expert review of medical devices

VOLUME: 3

Page Numbers: 817-34

Journal Abbreviation:

ISSN: 1743-4440

DAY: 3

MONTH: Nov

YEAR: 2006

Bioprosthetic heart valve heterograft biomaterials: structure, mechanical behavior and computational simulation. Information

Number of References: 109

LANGUAGE: eng

NlmUniqueID: 101230445

Bioprosthetic heart valve heterograft biomaterials: structure, mechanical behavior and computational simulation. Keywords Mesh Terms:

KEYWORDS: Transplantation, Heterologous

MESH TERMS: chemistry

Chemical & Substance for Abstract: Bioprosthetic heart valve heterograft biomaterials: structure, mechanical behavior and computational simulation. Information

Substance Name: Biocompatible Materials

Registry Number: 0

Grant and Affiliation Information for Bioprosthetic heart valve heterograft biomaterials: structure, mechanical behavior and computational simulation.

AFFILIATION: Engineered Tissue Mechanics Laboratory, Department of Bioengineering and the McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA. msacks@pitt.edu

Country: England

AGENCY: United States NHLBI

GRANT: HL74731

ACRONYM: HL

MEDLINETA: Expert Rev Med Devices

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