Biomimetic interfacial interpenetrating polymer networks control neural stem cell behavior.

Biomimetic interfacial interpenetrating polymer networks control neural stem cell behavior. Research Abstract Details 

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Biomimetic interfacial interpenetrating polymer networks control neural stem cell behavior. Abstract Text:

Krishanu Saha,Elizabeth F Irwin,Julia Kozhukh,David V Schaffer,Kevin E Healy,

Highly-regulated signals surrounding stem cells, such as growth factors at specific concentrations and matrix mechanical stiffness, have been implicated in modulating stem cell proliferation and maturation. However, tight control of proliferation and lineage commitment signals is rarely achieved during growth outside the body, since the spectrum of biochemical and mechanical signals that govern stem cell renewal and maturation are not fully understood. Therefore, stem cell control can potentially be enhanced through the development of material platforms that more precisely orchestrate signal presentation to stem cells. Using a biomimetic interfacial interpenetrating polymer network (IPN), we define a robust synthetic and highly-defined platform for the culture of adult neural stem cells. IPNs modified with two cell-binding ligands, CGGNGEPRGDTYRAY from bone sialoprotein [bsp-RGD(15)] and CSRARKQAASIKVAVSADR from laminin [lam-IKVAV(19)], were assayed for their ability to regulate self-renewal and differentiation in a dose-dependent manner. IPNs with >5.3 pmol/cm(2) bsp-RGD(15) supported both self-renewal and differentiation, whereas IPNs with lam-IKVAV(19) failed to support stem cell adhesion and did not influence differentiation. The IPN platform is highly tunable to probe stem cell signal transduction mechanisms and to control stem cell behavior in vitro.

Biomimetic interfacial interpenetrating polymer networks control neural stem cell behavior. Publishing Authors By Initials

K Saha,EF Irwin,J Kozhukh,DV Schaffer,KE Healy,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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MEDLINE DATE:

Biomimetic interfacial interpenetrating polymer networks control neural stem cell behavior. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of biomedical materials research. Part A

VOLUME: 81

Page Numbers: 240-9

Journal Abbreviation:

ISSN: 1549-3296

DAY: 3

MONTH: Apr

YEAR: 2007

Biomimetic interfacial interpenetrating polymer networks control neural stem cell behavior. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101234237

Biomimetic interfacial interpenetrating polymer networks control neural stem cell behavior. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Biomimetic interfacial interpenetrating polymer networks control neural stem cell behavior. Information

Substance Name: laminin 1

Registry Number: 0

Grant and Affiliation Information for Biomimetic interfacial interpenetrating polymer networks control neural stem cell behavior.

AFFILIATION: Department of Chemical Engineering, University of California at Berkeley, Berkeley, CA, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: AR 43187-07

ACRONYM: AR

MEDLINETA: J Biomed Mater Res A

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