Biomimetic interactions of proteins with functionalized nanoparticles: a thermodynamic study.

Biomimetic interactions of proteins with functionalized nanoparticles: a thermodynamic study. Research Abstract Details 

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Biomimetic interactions of proteins with functionalized nanoparticles: a thermodynamic study. Abstract Text:

Mrinmoy De,Chang-Cheng You,Sudhanshu Srivastava,Vincent M Rotello,

Gold nanoparticles (NPs) functionalized with L-amino acid-terminated monolayers provide an effective platform for the recognition of protein surfaces. Isothermal titration calorimetry (ITC) was used to quantify the binding thermodynamics of these functional NPs with alpha-chymotrypsin (ChT), histone, and cytochrome c (CytC). The enthalpy and entropy changes for the complex formation depend upon the nanoparticle structure and the surface characteristics of the proteins, e.g., distributions of charged and hydrophobic residues on the surface. Enthalpy-entropy compensation studies on these NP-protein systems indicate an excellent linear correlation between DeltaH and TDeltaS with a slope (alpha) of 1.07 and an intercept (TDeltaS0) of 35.2 kJ mol(-1). This behavior is closer to those of native protein-protein systems (alpha = 0.92 and TDeltaS0 = 41.1 kJ mol(-1)) than other protein-ligand and synthetic host-guest systems.

Biomimetic interactions of proteins with functionalized nanoparticles: a thermodynamic study. Publishing Authors By Initials

M De,CC You,S Srivastava,VM Rotello,

For similar natural sciences: physics: thermodynamics research abstracts see: natural sciences: physics: thermodynamics research

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MEDLINE DATE:

Biomimetic interactions of proteins with functionalized nanoparticles: a thermodynamic study. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 129

Page Numbers: 10747-53

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 2

MONTH: 08

YEAR: 2007

Biomimetic interactions of proteins with functionalized nanoparticles: a thermodynamic study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

Biomimetic interactions of proteins with functionalized nanoparticles: a thermodynamic study. Keywords Mesh Terms:

KEYWORDS: Thermodynamics

MESH TERMS: chemistry

Chemical & Substance for Abstract: Biomimetic interactions of proteins with functionalized nanoparticles: a thermodynamic study. Information

Substance Name: Chymotrypsin

Registry Number: EC 3.4.21.1

Grant and Affiliation Information for Biomimetic interactions of proteins with functionalized nanoparticles: a thermodynamic study.

AFFILIATION: Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM077173

ACRONYM: GM

MEDLINETA: J Am Chem Soc

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