Biomechanics of the porcine basilar artery in hypertension.

Biomechanics of the porcine basilar artery in hypertension. Research Abstract Details 

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Biomechanics of the porcine basilar artery in hypertension. Abstract Text:

J-J Hu,T W Fossum,M W Miller,H Xu,J-C Liu,J D Humphrey,

Hypertension is a significant risk factor for diverse cerebrovascular diseases ranging from stroke to arteriovenous malformations and saccular aneurysms. Our increasing understanding of vascular mechanobiology reveals that changes in mechanical stimuli, such as increased blood pressure, alter basic cellular functions including the production and degradation of extracellular matrix as well as proliferation, migration, and apoptosis. Understanding changes in the biomechanical properties of the vascular wall is fundamental to correlating mechanobiological responses with the altered loads. In this paper, we present the first biomechanical data on a large cerebral artery in terms of the time of development of hypertension in maturity. Specifically, we report rapid changes in both the structural and the material stiffness of the passive basilar artery in a novel aortic-coarctation model of hypertension in the mini-pig. Histological measurements reveal associated increases in fibrillar collagens in the media and adventitia as well as increased smooth muscle in the media. That such dramatic changes occur within 2 weeks of the initiation of hypertension in maturity necessitates a detailed study of the early changes as well as the potential to reverse these changes at later times.

Biomechanics of the porcine basilar artery in hypertension. Publishing Authors By Initials

JJ Hu,TW Fossum,MW Miller,H Xu,JC Liu,JD Humphrey,

For similar animals: chordata: vertebrates: mammals: artiodactyla: swine research abstracts see: animals: chordata: vertebrates: mammals: artiodactyla: swine research

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Biomechanics of the porcine basilar artery in hypertension. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Annals of biomedical engineering

VOLUME: 35

Page Numbers: 19-29

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ISSN: 0090-6964

DAY: 26

MONTH: 10

YEAR: 2006

Biomechanics of the porcine basilar artery in hypertension. Information

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LANGUAGE: eng

NlmUniqueID: 361512

Biomechanics of the porcine basilar artery in hypertension. Keywords Mesh Terms:

KEYWORDS: Swine

MESH TERMS: physiopathology

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Grant and Affiliation Information for Biomechanics of the porcine basilar artery in hypertension.

AFFILIATION: Department of Biomedical Engineering, Texas A&M University, 337 Zachry Engineering Center, 3120 TAMU, College Station, TX 77843-3120, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL 80415

ACRONYM: HL

MEDLINETA: Ann Biomed Eng

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