Biological selection of peptides for poly(l-lactide) substrates.

Biological selection of peptides for poly(l-lactide) substrates. Research Abstract Details 

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Biological selection of peptides for poly(l-lactide) substrates. Abstract Text:

Short peptides that recognize the alpha form of poly( l-lactide) (PLLA) crystalline films were identified from a phage-displayed peptide library. An enzyme-linked immunosorbent assay (ELISA) revealed that the apparent binding constants of the phage clones for the alpha form of PLLA were greater than those of the unselected phage library. The specificity index for the alpha form of PLLA referred to a structurally similar atactic poly(methyl methacrylate) (at-PMMA), supporting the alpha form of PLLA specific binding of the selected phage. Amino acid residues with proton-donor lateral groups and hydrophobic alkyl groups were relatively enriched in a sequence of heptapeptides on the specific phage clones, thereby suggesting the presence of hydrogen bonding as well as hydrophobic interactions between the alpha form of PLLA and the peptides. Surface plasmon resonance (SPR) analysis revealed that the binding constant of the freed c22 heptapeptide (Gln-Leu-Met-His-Asp-Tyr-Arg) for the alpha form of PLLA was greater than those for reference at-PMMA, amorphous PLLA, and the beta form of PLLA. It was found that c22 peptide can recognize slight differences in PLLA polymorphs such as a crystalline state and an arrangement of PLLA functional groups.

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Biological selection of peptides for poly(l-lactide) substrates. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Langmuir : the ACS journal of surfaces and colloid

VOLUME: 24

Page Numbers: 6399-403

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ISSN: 0743-7463

DAY: 24

MONTH: 05

YEAR: 2008

Biological selection of peptides for poly(l-lactide) substrates. Information

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LANGUAGE: eng

NlmUniqueID: 9882736

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Grant and Affiliation Information for Biological selection of peptides for poly(l-lactide) substrates.

AFFILIATION: Komaba Open Laboratory, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan.

Country: United States

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MEDLINETA: Langmuir

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