Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines.

Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines. Research Abstract Details 

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Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines. Abstract Text:

Adebusola A Alagbala,Andrew J McRiner,Kristina Borstnik,Tanzina Labonte,Wonsuk Chang,John G D'Angelo,Gary H Posner,Barbara A Foster,

The mechanisms of action of three C-10 non-acetal trioxane dimers (TDs) were examined in human (LNCaP) and mouse (TRAMP-C1A and -C2H) prostate cancer cell lines. 1 (AJM3/23), 2 (GHP-TM-III-07w), and 3 (GHP-KB-06) inhibited cell growth with 3 being the most potent in C1A (GI50 = 18.0 nM), C2H (GI50 = 17.0 nM), and LNCaP (GI50 = 17.9 nM) cells. In comparison to a standard cytotoxic agent such as doxorubicin (GI50 = 45.3 nM), 3 (GI50 = 17.9 nM) inhibited LNCaP cell growth more potently. TDs induced G0/G1 cell cycle arrest in LNCaP cells and decreased cells in the S phase. These changes correlated with modulation of G1 phase cell cycle proteins including decreased cyclin D1, cyclin E, and cdk2 and increased p21waf1 and p27Kip1. TDs also promoted apoptosis in LNCaP cells with increased expression of proapoptotic bax. These results demonstrate that TDs are potentially useful agents that warrant further preclinical development for treatment of prostate cancer.

Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines. Publishing Authors By Initials

AA Alagbala,AJ McRiner,K Borstnik,T Labonte,W Chang,JG D'Angelo,GH Posner,BA Foster,

For similar cells: cells, cultured: tumor cells, cultured research abstracts see: cells: cells, cultured: tumor cells, cultured research

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Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of medicinal chemistry

VOLUME: 49

Page Numbers: 7836-42

Journal Abbreviation: J. Med. Chem.

ISSN: 0022-2623

DAY: 28

MONTH: Dec

YEAR: 2006

Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9716531

Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines. Keywords Mesh Terms:

KEYWORDS: Tumor Cells, Cultured

MESH TERMS: drug effects

Chemical & Substance for Abstract: Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines. Information

Substance Name: Doxorubicin

Registry Number: 23214-92-8

Grant and Affiliation Information for Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines.

AFFILIATION: Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI 34885

ACRONYM: AI

MEDLINETA: J Med Chem

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