Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue.

Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. Research Abstract Details 

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Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. Abstract Text:

Reza Izadpanah,Cynthia Trygg,Bindiya Patel,Christopher Kriedt,Jason Dufour,Jeffery M Gimble,Bruce A Bunnell,

The biologic characteristics of mesenchymal stem cells (MSCs) isolated from two distinct tissues, bone marrow and adipose tissue were evaluated in these studies. MSCs derived from human and non-human primate (rhesus monkey) tissue sources were compared. The data indicate that MSCs isolated from rhesus bone marrow (rBMSCs) and human adipose tissue (hASCs) had more similar biologic properties than MSCs of rhesus adipose tissue (rASCs) and human bone marrow MSCs (hBMSCs). Analyses of in vitro growth kinetics revealed shorter doubling time for rBMSCs and hASCs. rBMSCs and hASCs underwent significantly more population doublings than the other MSCs. MSCs from all sources showed a marked decrease in telomerase activity over extended culture; however, they maintained their mean telomere length. All of the MSCs expressed embryonic stem cell markers, Oct-4, Rex-1, and Sox-2 for at least 10 passages. Early populations of MSCs types showed similar multilineage differentiation capability. However, only the rBMSCs and hASCs retain greater differentiation efficiency at higher passages. Overall in vitro characterization of MSCs from these two species and tissue sources revealed a high level of common biologic properties. However, the results demonstrate clear biologic distinctions, as well.

Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. Publishing Authors By Initials

R Izadpanah,C Trygg,B Patel,C Kriedt,J Dufour,JM Gimble,BA Bunnell,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of cellular biochemistry

VOLUME: 99

Page Numbers: 1285-97

Journal Abbreviation: J. Cell. Biochem.

ISSN: 0730-2312

DAY: 1

MONTH: Dec

YEAR: 2006

Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8205768

Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. Information

Substance Name: Telomerase

Registry Number: EC 2.7.7.49

Grant and Affiliation Information for Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue.

AFFILIATION: Division of Gene Therapy, Tulane National Primate Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA.

Country: United States

AGENCY: United States NCRR

GRANT: RR00164

ACRONYM: RR

MEDLINETA: J Cell Biochem

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