Biologic and clinical significance of cytokine production in B-cell malignancies.

Biologic and clinical significance of cytokine production in B-cell malignancies. Research Abstract Details 

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Biologic and clinical significance of cytokine production in B-cell malignancies. Abstract Text:

Cytokines are a group of polypeptide hormones endowed with pleiotropic biological properties. Normal B lymphocytes produce a number of these factors that subserve important regulatory functions in the combined processes of proliferation and differentiation. Also neoplastic B cells can release cytokines and, simultaneously, respond to the same factors in an autocrine circuit that supports their malignant growth. In addition, tumor cells can make use of the factors released by normal cells, either spontaneously or under the influence of inductive signals from the neoplastic cells. Inappropriate or excessive release of cytokines may have an important role in the pathophysiology of some clinical features. Thus, neutralization of cytokine biologic activity in vivo could be a therapeutic strategy for treatment of human B-cell neoplasias.

Biologic and clinical significance of cytokine production in B-cell malignancies. Publishing Authors By Initials

For similar proteins: neoplasm proteins research abstracts see: proteins: neoplasm proteins research

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Biologic and clinical significance of cytokine production in B-cell malignancies. Journal Published:

PUBLICATION TYPE: Review

Journal: European journal of haematology. Supplementum

VOLUME: 51

Page Numbers: 35-42

Journal Abbreviation:

ISSN: 0902-4506

DAY: 26

MONTH: 02

YEAR: 1989

Biologic and clinical significance of cytokine production in B-cell malignancies. Information

Number of References: 62

LANGUAGE: eng

NlmUniqueID: 8703474

Biologic and clinical significance of cytokine production in B-cell malignancies. Keywords Mesh Terms:

KEYWORDS: Neoplasm Proteins

MESH TERMS: secretion

Chemical & Substance for Abstract: Biologic and clinical significance of cytokine production in B-cell malignancies. Information

Substance Name: Neoplasm Proteins

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Grant and Affiliation Information for Biologic and clinical significance of cytokine production in B-cell malignancies.

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Country: DENMARK

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MEDLINETA: Eur J Haematol Suppl

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