Bioinformatic identification of genes encoding C1q-domain-containing proteins in zebrafish.

Bioinformatic identification of genes encoding C1q-domain-containing proteins in zebrafish. Research Abstract Details 

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Bioinformatic identification of genes encoding C1q-domain-containing proteins in zebrafish. Abstract Text:

Jie Mei,Jianfang Gui,

C1q is the first subcomponent of classical pathway in the complement system and a major link between innate and acquired immunities. The globular (gC1q) domain similar with C1q was also found in many non-complement C1q-domain-containing (C1qDC) proteins which have similar crystal structure to that of the multifunctional tumor necrosis factor (TNF) ligand family, and also have diverse functions. In this study, we identified a total of 52 independent gene sequences encoding C1q-domain-containing proteins through comprehensive searches of zebrafish genome, cDNA and EST databases. In comparison to 31 orthologous genes in human and different numbers in other species, a significant selective pressure was suggested during vertebrate evolution. Domain organization of C1q-domain-containing (C1qDC) proteins mainly includes a leading signal peptide, a collagen-like region of variable length, and a C-terminal C1q domain. There are 11 highly conserved residues within the C1q domain, among which 2 are invariant within the zebrafish gene set. A more extensive database searches also revealed homologous C1qDC proteins in other vertebrates, invertebrates and even bacterium, but no homologous sequences for encoding C1qDC proteins were found in many species that have a more recent evolutionary history with zebrafish. Therefore, further studies on C1q-domain-containing genes among different species will help us understand evolutionary mechanism of innate and acquired immunities.

Bioinformatic identification of genes encoding C1q-domain-containing proteins in zebrafish. Publishing Authors By Initials

J Mei,J Gui,

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Bioinformatic identification of genes encoding C1q-domain-containing proteins in zebrafish. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of genetics and genomics = Yi chuan xue ba

VOLUME: 35

Page Numbers: 17-24

Journal Abbreviation: J Genet Genomics

ISSN: 1673-8527

DAY: 28

MONTH: Jan

YEAR: 2008

Bioinformatic identification of genes encoding C1q-domain-containing proteins in zebrafish. Information

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LANGUAGE: eng

NlmUniqueID: 101304616

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Grant and Affiliation Information for Bioinformatic identification of genes encoding C1q-domain-containing proteins in zebrafish.

AFFILIATION: State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China; Graduate School of the Chinese Academy of Sciences, Beijing 100049, China.

Country: China

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MEDLINETA: J Genet Genomics

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