Biocompatibility of fluorinated poly(organophosphazene).

Biocompatibility of fluorinated poly(organophosphazene). Research Abstract Details 

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Biocompatibility of fluorinated poly(organophosphazene). Abstract Text:

Shota Kanezaki,Hiroyoshi Kawakami,Shoji Nagaoka,Sunao Kubota,

We investigated neutrophil and platelet adhesion on a fluorinated poly(organophosphazene) in vitro. The results suggested that neutrophil and platelet adhesion on the poly(organophosphazene) only occurred on a few occasions, as observed by SEM. We demonstrated that the fluorinated poly(organophosphazene) showed excellent biocompatibility compared with the poly(organophosphazene) without the fluorinated side groups or PDMS. Additionally, we estimated the competitive plasma protein adsorption to the fluorinated poly(organophosphazene) using a gold-colloid-labeled immunoassay. Interestingly, the fluorinated poly(organophosphazene) film selectively adsorbed albumin when compared with gamma-globulin and fibrinogen, suggesting that a selective albumin adsorption on the film is responsible for the suppression of platelet adhesion.

Biocompatibility of fluorinated poly(organophosphazene). Publishing Authors By Initials

S Kanezaki,H Kawakami,S Nagaoka,S Kubota,

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Biocompatibility of fluorinated poly(organophosphazene). Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 14

Page Numbers: 469-79

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 2003

Biocompatibility of fluorinated poly(organophosphazene). Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9007393

Biocompatibility of fluorinated poly(organophosphazene). Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Biocompatibility of fluorinated poly(organophosphazene). Information

Substance Name: Fluorine

Registry Number: 7782-41-4

Grant and Affiliation Information for Biocompatibility of fluorinated poly(organophosphazene).

AFFILIATION: Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397, Japan.

Country: Netherlands

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MEDLINETA: J Biomater Sci Polym Ed

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