Biochemistry of PUFA double bond isomerases producing conjugated linoleic acid.

Biochemistry of PUFA double bond isomerases producing conjugated linoleic acid. Research Abstract Details 

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Biochemistry of PUFA double bond isomerases producing conjugated linoleic acid. Abstract Text:

The biotransformation of linoleic acid (LA) into conjugated linoleic acid (CLA) by microorganisms is a potentially useful industrial process. In most cases, however, the identities of proteins involved and the details of enzymatic activity regulation are far from clear. Here we summarize available data on the reaction mechanisms of CLA-producing enzymes characterized until now, from Butyrivibrio fibrisolvens, Lactobacillus acidophilus, Ptilota filicina, and Propionibacterium acnes. A general feature of enzymatic LA isomerization is the protein-assisted abstraction of an aliphatic hydrogen atom from position C-11, while the role of flavin as cofactor for the double bond activation in CLA-producing enzymes is also discussed with regard to the recently published three-dimensional structure of an isomerase from P. acnes. Combined data from structural studies, isotopic labeling experiments, and sequence comparison suggest that at least two different prototypical active site geometries occur among polyunsaturated fatty acid (PUFA) double bond isomerases.

Biochemistry of PUFA double bond isomerases producing conjugated linoleic acid. Publishing Authors By Initials

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Biochemistry of PUFA double bond isomerases producing conjugated linoleic acid. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Chembiochem : a European journal of chemical biolo

VOLUME: 9

Page Numbers: 1867-72

Journal Abbreviation: Chembiochem

ISSN: 1439-7633

DAY: 11

MONTH: Aug

YEAR: 2008

Biochemistry of PUFA double bond isomerases producing conjugated linoleic acid. Information

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LANGUAGE: eng

NlmUniqueID: 100937360

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Grant and Affiliation Information for Biochemistry of PUFA double bond isomerases producing conjugated linoleic acid.

AFFILIATION: Georg August University, Albrecht von Haller Institute for Plant Sciences, Department of Plant Biochemistry, Justus-von-Liebig Weg 11, 37077 Göttingen, Germany.

Country: Germany

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MEDLINETA: Chembiochem

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