Biochemical mechanisms of nephrotoxicity: application for metabolomics.

Biochemical mechanisms of nephrotoxicity: application for metabolomics. Research Abstract Details 

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Biochemical mechanisms of nephrotoxicity: application for metabolomics. Abstract Text:

Claus U Niemann,Natalie J Serkova,

This review describes biochemical pathways of nephrotoxicity and the application of metabolic biomarkers as they relate to nephrotoxicity. Specific and sensitive biomarkers constitute the missing link in the continuum of exposure to toxins and susceptibility, disease development and possible therapeutic intervention. Important requirements for biomarker development are a detailed understanding of biochemical pathways involved in nephrotoxicity, minimal invasiveness and capacity to screen large at-risk populations. Lastly, possible biomarker candidates should be organ specific and equally applicable in preclinical drug testing as well as in clinical care of patients. This review discusses four major metabolic pathways associated with disturbed renal homeostasis: i) direct metabolic evidence of abnormal excretion of endogenous metabolites; ii) disturbances in kidney osmolarity and renal osmolyte homeostasis; iii) impaired energy state followed by dysregulation of glucose, fatty acid and ketone body metabolism; and iv) oxidative stress in renal tissues. Each of these pathways can be monitored by specific surrogate markers in urine and blood using modern metabolomics technologies.

Biochemical mechanisms of nephrotoxicity: application for metabolomics. Publishing Authors By Initials

CU Niemann,NJ Serkova,

For similar male urogenital diseases: urologic diseases: kidney diseases research abstracts see: male urogenital diseases: urologic diseases: kidney diseases research

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Biochemical mechanisms of nephrotoxicity: application for metabolomics. Journal Published:

PUBLICATION TYPE: Review

Journal: Expert opinion on drug metabolism & toxicology

VOLUME: 3

Page Numbers: 527-44

Journal Abbreviation:

ISSN: 1742-5255

DAY: 3

MONTH: Aug

YEAR: 2007

Biochemical mechanisms of nephrotoxicity: application for metabolomics. Information

Number of References: 75

LANGUAGE: eng

NlmUniqueID: 101228422

Biochemical mechanisms of nephrotoxicity: application for metabolomics. Keywords Mesh Terms:

KEYWORDS: Kidney Diseases

MESH TERMS: pathology

Chemical & Substance for Abstract: Biochemical mechanisms of nephrotoxicity: application for metabolomics. Information

Substance Name: Biological Markers

Registry Number: 0

Grant and Affiliation Information for Biochemical mechanisms of nephrotoxicity: application for metabolomics.

AFFILIATION: University of California San Francisco, Division of Transplantation, Department of Anesthesia and Perioperative Care, San Francisco, California, USA.

Country: England

AGENCY: United States NCI

GRANT: P30 CA046934

ACRONYM: CA

MEDLINETA: Expert Opin Drug Metab Toxicol

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