Bioactive nanofibers: synergistic effects of nanotopography and chemical signaling on cell guidance.

Bioactive nanofibers: synergistic effects of nanotopography and chemical signaling on cell guidance. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Bioactive nanofibers: synergistic effects of nanotopography and chemical signaling on cell guidance. Abstract Text:

Shyam Patel,Kyle Kurpinski,Ryan Quigley,Hongfeng Gao,Benjamin S Hsiao,Mu-Ming Poo,Song Li,

Biodegradable nanofibers have tremendous potential for tissue repair. However, the combined effects of nanofiber organization and immobilized bioactive factors on cell guidance are not well understood. In this study, we developed aligned and bioactive nanofibrous scaffolds by immobilizing extracellular matrix protein and growth factor onto nanofibers, which simulated the physical and biochemical properties of native matrix fibrils. The aligned nanofibers significantly induced neurite outgrowth and enhanced skin cell migration during wound healing compared to randomly oriented nanofibers. Furthermore, the immobilized biochemical factors (as efficient as soluble factors) synergized with aligned nanofibers to promote highly efficient neurite outgrowth but had less effect on skin cell migration. This study shed light on the relative importance of nanotopography and chemical signaling in the guidance of different cell behavior.

Bioactive nanofibers: synergistic effects of nanotopography and chemical signaling on cell guidance. Publishing Authors By Initials

S Patel,K Kurpinski,R Quigley,H Gao,BS Hsiao,MM Poo,S Li,

For similar integumentary system: skin research abstracts see: integumentary system: skin research

PUBMED ID PMID:

MEDLINE DATE:

Bioactive nanofibers: synergistic effects of nanotopography and chemical signaling on cell guidance. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nano letters

VOLUME: 7

Page Numbers: 2122-8

Journal Abbreviation: Nano Lett.

ISSN: 1530-6984

DAY: 14

MONTH: 06

YEAR: 2007

Bioactive nanofibers: synergistic effects of nanotopography and chemical signaling on cell guidance. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101088070

Bioactive nanofibers: synergistic effects of nanotopography and chemical signaling on cell guidance. Keywords Mesh Terms:

KEYWORDS: Skin

MESH TERMS: cytology

Chemical & Substance for Abstract: Bioactive nanofibers: synergistic effects of nanotopography and chemical signaling on cell guidance. Information

Substance Name: Biocompatible Materials

Registry Number: 0

Grant and Affiliation Information for Bioactive nanofibers: synergistic effects of nanotopography and chemical signaling on cell guidance.

AFFILIATION: Joint Graduate Program in Bioengineering, University of California San Francisco, University of California Berkeley, California 94720-1762, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS22764

ACRONYM: NS

MEDLINETA: Nano Lett

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Bioactive nanofibers: synergistic effects of nanotopography and chemical signaling on cell guidance Related Publications

• Airway epithelium and mucus: intracellular signaling pathways for gene expression and secretion.
• Imaging diagnosis of enlarged superior ophthalmic vein.
• Lung autotransplantation technique for treating central lung cancer of upper lobe.
• Study on the relationship between opioid receptors and fetal distress.
• The clinical value of rearrangement of IgH gene and bcl-2/J(H) fuse gene in the diagnosis of orbital lymphoproliferative disorders.
• The effect of metal copper on fracture healing in chicken.
• Transforming growth factor-beta -Smad signaling pathway cooperates with NF-kappa B to mediate nontypeable Haemophilus influenzae-induced MUC2 mucin transcription.
• [Advances in research on ion-channel gating mechanism]
• [Association of dendritic cell infiltration with prognosis and lymph node metastasis of renal cell carcinoma]
• [Changes in serum concentration of podophyllotoxin after its topical application with liposome on rat skin]
• [ECG signal compression based on best basis of wavelet packets]
• [Effect of lovastatin on proliferation and extracellular matrix secretion of rat hepatic stellate cells in vitro]
• [Effects of hypoxic exposure on coordinative expression of cytochrome oxidase subunits I and IV in rat cerebral cortex]
• [Effects of nitric oxide on pleural lymphatic stomata and lymphatic drainage in the rat]
• [Evaluation of p53, p21waf1, and PCNA in the diagnosis on lung cancer]
• [Evaluation the pathological diagnostic values of koilocyte in condyloma acuminatum]
• [Gap junctions in the nervous tissue]
• [Genotyping of HIV resistant alleles in indigenous Tibetan ethnic group of China: low frequency of CCR5triangle32 and high frequency of CCR2b-64I alleles]
• [Logistic regression analysis of wedge-shaped defects in the middle-aged and elderly]
• [Molecular genetic basis of Gilbert's syndrome]
• [Observation on the effect of disinfection to HBsAg by electrolyzed oxidizing water]
• [P2X purinoceptors and their regulations]
• [Preparation of rhBMP-2/BCB reconstituted bone xenograft and assay of its osteoinductivity]
• [Selective transmission of hepatitis B virus variant with S gene mutation between HBV-carrier mothers and their infants]
• [Surgical repair of postinfarction ventricular septal rupture]
• [Surgical treatment of anomalous origin of the left coronary artery from the pulmonary artery]
• [The correlations between plasma TNF-alpha, NO, NOS levels and brain lateralization in mice]
• [The genotype analysis of glucose-6-phosphate dehydrogenase deficiency in Yunnan province]
• [The relationship of low density lipoprotein receptor gene polymorphism and hyperlipidemia]
• [Umbilical cord blood transplantation (UCBT) in thalassemia children]