Bioactive hydrogel-filament scaffolds for nerve repair and regeneration.

Bioactive hydrogel-filament scaffolds for nerve repair and regeneration. Research Abstract Details 

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Bioactive hydrogel-filament scaffolds for nerve repair and regeneration. Abstract Text:

K D Newman,C R McLaughlin,D Carlsson,F Li,Y Liu,M Griffith,K D Newman,C R McLaughlin,D Carlsson,F Li,Y Liu,M Griffith,K D Newman,C R McLaughlin,D Carlsson,F Li,Y Liu,M Griffith,

The design of novel biomaterials is crucial for the advancement of tissue engineering in nerve regeneration. In this study we developed and evaluated novel biosynthetic scaffolds comprising collagen crosslinked with a terpolymer of poly(N-isopropylacrylamide) (PNiPAAm) as conduits for nerve growth. These collagen-terpolymer (collagen-TERP) scaffolds grafted with the laminin pentapeptide YIGSR were previously used as corneal substitutes in pigs and demonstrated enhanced nerve regeneration compared to allografts. The purpose of this project was to enhance neuronal growth on the collagen-TERP scaffolds through the incorporation of supporting fibers. Neuronal growth on these matrices was assessed in vitro using isolated dorsal root ganglia as a nerve source. Statistical significance was assessed using a one-way ANOVA. The incorporation of fibers into the collagen-TERP scaffolds produced a significant increase in neurite extension (p<0.05). The growth habit of the nerves varied with the type of fiber and included directional growth of the neurites along the surface of certain fiber types. Furthermore, the presence of fibers in the collagen-TERP scaffolds appeared to influence neurite morphology and function; neurites grown on fibers-incorporated collagen-TERP scaffolds expressed higher levels of Na channels compared to the scaffolds without fiber. Overall, our results suggest that incorporation of supporting fibers enhanced neurite outgrowth and that surface properties of the scaffold play an important role in promoting and guiding nerve regeneration. More importantly, this study demonstrates the potential value of tissue engineered collagen-TERP hybrid scaffolds as conduits in peripheral nerve repair.

Bioactive hydrogel-filament scaffolds for nerve repair and regeneration. Publishing Authors By Initials

KD Newman,CR McLaughlin,D Carlsson,F Li,Y Liu,M Griffith,KD Newman,CR McLaughlin,D Carlsson,F Li,Y Liu,M Griffith,KD Newman,CR McLaughlin,D Carlsson,F Li,Y Liu,M Griffith,

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Bioactive hydrogel-filament scaffolds for nerve repair and regeneration. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The International journal of artificial organs

VOLUME: 29

Page Numbers: 1082-91

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ISSN: 0391-3988

DAY: 12

MONTH: Nov

YEAR: 2006

Bioactive hydrogel-filament scaffolds for nerve repair and regeneration. Information

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LANGUAGE: eng

NlmUniqueID: 7802649

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Grant and Affiliation Information for Bioactive hydrogel-filament scaffolds for nerve repair and regeneration.

AFFILIATION: University of Ottawa Eye Institute, Ottawa Hospital, General Campus, Ottawa, Ontario - Canada.

Country: Italy

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MEDLINETA: Int J Artif Organs

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