BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities.

BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities. Research Abstract Details 

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BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities. Abstract Text:

Tiqing Liu,Yuhmei Lin,Xin Wen,Robert N Jorissen,Michael K Gilson,

BindingDB (http://www.bindingdb.org) is a publicly accessible database currently containing approximately 20,000 experimentally determined binding affinities of protein-ligand complexes, for 110 protein targets including isoforms and mutational variants, and approximately 11,000 small molecule ligands. The data are extracted from the scientific literature, data collection focusing on proteins that are drug-targets or candidate drug-targets and for which structural data are present in the Protein Data Bank. The BindingDB website supports a range of query types, including searches by chemical structure, substructure and similarity; protein sequence; ligand and protein names; affinity ranges and molecular weight. Data sets generated by BindingDB queries can be downloaded in the form of annotated SDfiles for further analysis, or used as the basis for virtual screening of a compound database uploaded by the user. The data in BindingDB are linked both to structural data in the PDB via PDB IDs and chemical and sequence searches, and to the literature in PubMed via PubMed IDs.

BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities. Publishing Authors By Initials

T Liu,Y Lin,X Wen,RN Jorissen,MK Gilson,

For similar information science: computing methodologies: software: user-computer interface research abstracts see: information science: computing methodologies: software: user-computer interface research

PUBMED ID PMID:

MEDLINE DATE:

BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Nucleic acids research

VOLUME: 35

Page Numbers: D198-201

Journal Abbreviation: Nucleic Acids Res.

ISSN: 1362-4962

DAY: 1

MONTH: 12

YEAR: 2006

BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 411011

BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities. Keywords Mesh Terms:

KEYWORDS: User-Computer Interface

MESH TERMS: metabolism

Chemical & Substance for Abstract: BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities. Information

Substance Name: Proteins

Registry Number: 0

Grant and Affiliation Information for BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities.

AFFILIATION: Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, MD 20850, USA.

Country: England

AGENCY: United States NIGMS

GRANT: GM070064

ACRONYM: GM

MEDLINETA: Nucleic Acids Res

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