Binding effect of the antitumor active dirhodium (II) compounds to plasmid DNA.

Binding effect of the antitumor active dirhodium (II) compounds to plasmid DNA. Research Abstract Details 

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Binding effect of the antitumor active dirhodium (II) compounds to plasmid DNA. Abstract Text:

Md Masudur Rahman,Hachiro Yasuda,Kazunori Takashima,Akira Mizuno,

Binding effect of the antitumor dirhodium (II) compounds to the plasmid pUC19 DNA has been studied under different molar ratio of Rh (II) compounds to base pair of pUC19 DNA (Rf) and time. The electrophoresis results indicate that Rh binding affect the DNA conformation and therefore, Rh-DNA migrated in the different position comparing with native DNA. At high value of Rf ICP-MS (Inductively Coupled Plasma Mass Spectrometry) measurement confirmed that 46% of Rh binds to DNA. In vitro result shows that DNA synthesis was inhibited by the Rh binding.

Binding effect of the antitumor active dirhodium (II) compounds to plasmid DNA. Publishing Authors By Initials

MM Rahman,H Yasuda,K Takashima,A Mizuno,

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Binding effect of the antitumor active dirhodium (II) compounds to plasmid DNA. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nucleic acids symposium series (2004)

VOLUME:

Page Numbers: 89-90

Journal Abbreviation: Nucleic Acids Symp Ser (Oxf)

ISSN: 1746-8272

DAY: 21

MONTH: 11

YEAR: 2007

Binding effect of the antitumor active dirhodium (II) compounds to plasmid DNA. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Binding effect of the antitumor active dirhodium (II) compounds to plasmid DNA.

AFFILIATION: Department of Ecological Engineering, Toyohashi University of Technology, Tempaku-cho, Toyohashi, Aichi, 441-8580, Japan.

Country: England

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MEDLINETA: Nucleic Acids Symp Ser (Oxf)

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