Bile acid transporters: structure, function, regulation and pathophysiological implications.

Bile acid transporters: structure, function, regulation and pathophysiological implications. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Bile acid transporters: structure, function, regulation and pathophysiological implications. Abstract Text:

Waddah A Alrefai,Ravinder K Gill,

Specific transporters expressed in the liver and the intestine, play a critical role in driving the enterohepatic circulation of bile acids. By preserving a circulating pool of bile acids, an important factor influencing bile flow, these transporters are involved in maintaining bile acid and cholesterol homeostasis. Enterohepatic circulation of bile acids is fundamentally composed of two major processes: secretion from the liver and absorption from the intestine. In the hepatocytes, the vectorial transport of bile acids from blood to bile is ensured by Na+ taurocholate co-transporting peptide (NTCP) and organic anion transport polypeptides (OATPs). After binding to a cytosolic bile acid binding protein, bile acids are secreted into the canaliculus via ATP-dependent bile salt excretory pump (BSEP) and multi drug resistant proteins (MRPs). Bile acids are then delivered to the intestinal lumen through bile ducts where they emulsify dietary lipids and cholesterol to facilitate their absorption. Intestinal epithelial cells reabsorb the majority of the secreted bile acids through the apical sodium dependent bile acid transporter (ASBT) and sodium independent organic anion transporting peptide (OATPs). Cytosolic ileal bile acid binding protein (IBABP) mediates the transcellular movement of bile acids to the basolateral membrane across which they exit the cells via organic solute transporters (OST). An essential role of bile acid transporters is evident from the pathology associated with their genetic disruption or dysregulation of their function. Malfunctioning of hepatic and intestinal bile acid transporters is implicated in the pathophysiology of cholestatic liver disease and the depletion of circulating pool of bile acids, respectively. Extensive efforts have been recently made to enhance our understanding of the structure, function and regulation of the bile acid transporters and exploring new potential therapeutics to treat bile acid or cholesterol related diseases. This review will highlight current knowledge about structure, function and molecular characterization of bile acid transporters and discuss the implications of their defects in various hepatic and intestinal disorders.

Bile acid transporters: structure, function, regulation and pathophysiological implications. Publishing Authors By Initials

WA Alrefai,RK Gill,

For similar proteins: carrier proteins: membrane transport proteins: ion pumps: symporters research abstracts see: proteins: carrier proteins: membrane transport proteins: ion pumps: symporters research

PUBMED ID PMID:

MEDLINE DATE:

Bile acid transporters: structure, function, regulation and pathophysiological implications. Journal Published:

PUBLICATION TYPE: Review

Journal: Pharmaceutical research

VOLUME: 24

Page Numbers: 1803-23

Journal Abbreviation: Pharm. Res.

ISSN: 0724-8741

DAY: 3

MONTH: 04

YEAR: 2007

Bile acid transporters: structure, function, regulation and pathophysiological implications. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8406521

Bile acid transporters: structure, function, regulation and pathophysiological implications. Keywords Mesh Terms:

KEYWORDS: Symporters

MESH TERMS: metabolism

Chemical & Substance for Abstract: Bile acid transporters: structure, function, regulation and pathophysiological implications. Information

Substance Name: sodium-bile acid cotransporter

Registry Number: 145420-23-1

Grant and Affiliation Information for Bile acid transporters: structure, function, regulation and pathophysiological implications.

AFFILIATION: Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA. walrefai@uic.edu

Country: United States

AGENCY: United States NIDDK

GRANT: DK71596

ACRONYM: DK

MEDLINETA: Pharm Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Bile acid transporters: structure, function, regulation and pathophysiological implications Related Publications

• A common mechanism underlies stretch activation and receptor activation of TRPC6 channels.
• Access to primary care for Medicare beneficiaries.
• Bile acid transporters: structure, function, regulation and pathophysiological implications.
• Energy sources for laparoscopic partial nephrectomy--critical appraisal.
• Functional genomics and schizophrenia: endophenotypes and mutant models.
• Gastroenterological research in domestic animals--past, present and future perspectives.
• Genetic control of the immune response to poly(Glu52Lys33Tyr15) in neonatally thymectomized high and low responder rats.
• Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion.
• Intraventricular dyssynchrony assessment by real-time three-dimensional echocardiography.
• Laboratory risk factors for hospital mortality in acutely admitted patients.
• Laparoscopic radical nephrectomy: morcellate or leave intact? Leave intact.
• Modulation of human Niemann-Pick C1-like 1 gene expression by sterol: Role of sterol regulatory element binding protein 2.
• Molecular characterization of sodium/proton exchanger 3 (NHE3) from the yellow fever vector, Aedes aegypti.
• NHE8 mediates amiloride-sensitive Na+/H+ exchange across mosquito Malpighian tubules and catalyzes Na+ and K+ transport in reconstituted proteoliposomes.
• Oncological outcomes of laparoscopic radical nephrectomy for renal cancer.
• Phylogenetic analysis of bacterial and archaeal species in symptomatic and asymptomatic endodontic infections.
• Portion size of campus takeaway foods and serving size estimates of common foods.
• Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection.
• Radiographer role extension in gynaecological brachytherapy.
• SCALEs: multiscale analysis of library enrichment.
• Shoulder injury - weightlifting: 1143: june 1 3:55 PM - 4:15 PM.
• Steroid hormones acutely regulate expression of a Nudix protein-encoding gene in the endometrial epithelium of sheep.
• The Analytical Quality of Point-of-Care Testing in the 'QAAMS' Model for Diabetes Management in Australian Aboriginal Medical Services.
• The effects of ACL deficiency on mediolateral translation and varus-valgus rotation.
• The heresy of the 'recent' reference.
• The influence of physical activity on quality of life in celiac disease patients: 2432: board #111 june 1 3:30 PM -5:00 PM.
• The origin of Kaposi sarcoma.
• The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome.
• Three-dimensional echocardiography: an alternative imaging choice for evaluation of tricuspid valve disorders.
• Transcription factor Sp4 regulates dendritic patterning during cerebellar maturation.