[Bifidobacterial supplement enhances the expression and excretion of intestinal sIgA in severely burned rats]

[Bifidobacterial supplement enhances the expression and excretion of intestinal sIgA in severely burned rats] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Bifidobacterial supplement enhances the expression and excretion of intestinal sIgA in severely burned rats] Abstract Text:

Zhong-tang Wang,Yong-ming Yao,Guang-xia Xiao,Wei-hong Cao,Zhi-yong Sheng,

OBJECTIVE: To investigate the potential effect of bifidobacterial supplement on intestinal mucosal immunity associated with severe burns. METHODS: Wistar rats were randomly divided into burn control group (BC group, n = 30), treatment group (BT group, n = 30), and sham-burn group (NC group, n = 10). Rats in BT group were fed bifidobacterial preparation (5 x 10(9) CFU/ml) after 30% total body surface area full-thickness burns, 1.5 ml, twice daily. Rats in BC group and NC group were fed normal saline, 1.5 ml, twice daily. Samples were taken on post-burn 1-, 3-, and 5-day. The incidence of bacterial translocation and bifidobacteria counts in the cecum mucosa were determined with standard methods. The sIgA levels in the mucus of the small intestine were measured by RIA. The positive sIgA expression in the lamina propria was detected by immunohistochemical staining. RESULTS: The incidence of bacterial translocation was 42% and 16% in BC and BT groups on post-burn day 3 (P = 0.004), 30% and 8% on day 5 (P = 0.002), respectively. Plasma endotoxin levels were markedly higher in BC and BT groups than in NC group at the early stage post-burn. There was a significant decrease between BT group and BC group on post-burn day 1 (P = 0.0412). Bifidobacteria counts in cecum mucosa were reduced by 10- to 60-fold after thermal injury, but there was a remarkable increase in bifidobacteria counts in animals fed with bifidobacteria. sIgA levels in the intestinal mucus were significantly decreased in group BC, but they returned to normal range in BT group on post-burn day 5. Similarly, sIgA expression in the lamina propria was also weakened after burns, and had a tendency to recover after prescription of a 5-day bifidobacteria-supplemented formula. A strong positive correlation was observed between the counts of bifidobacteria in the cecal mucosa and the levels of sIgA in the intestinal mucus (r = 0.7534, P = 0.0000). CONCLUSIONS: The expression and excretion of sIgA in the intestine appear to be markedly inhibited following a severe thermal injury. The supplement of exogenous bifidobacteria could improve sIgA formation in the small intestine, thereby reducing the incidence of bacterial/endotoxin translocation secondary to major burns.

[Bifidobacterial supplement enhances the expression and excretion of intestinal sIgA in severely burned rats] Publishing Authors By Initials

ZT Wang,YM Yao,GX Xiao,WH Cao,ZY Sheng,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Bifidobacterial supplement enhances the expression and excretion of intestinal sIgA in severely burned rats] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua wai ke za zhi [Chinese journal of surgery

VOLUME: 41

Page Numbers: 385-8

Journal Abbreviation: Zhonghua Wai Ke Za Zhi

ISSN: 0529-5815

DAY: 1

MONTH: May

YEAR: 2003

[Bifidobacterial supplement enhances the expression and excretion of intestinal sIgA in severely burned rats] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 153611

[Bifidobacterial supplement enhances the expression and excretion of intestinal sIgA in severely burned rats] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Bifidobacterial supplement enhances the expression and excretion of intestinal sIgA in severely burned rats] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Bifidobacterial supplement enhances the expression and excretion of intestinal sIgA in severely burned rats]

AFFILIATION: Burns Institute, 304th Hospital, People's Liberation Army, Beijing 100037, China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Zhonghua Wai Ke Za Zhi

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Bifidobacterial supplement enhances the expression and excretion of intestinal sIgA in severely burned rats Related Publications

• Skeletal myogenesis by human embryonic stem cells.
• [A comparative study of PDGF and EGF expression in skin wound healing between human fetal and adult]
• [Absorption spectra study for fullerene-doped in polystyrene film]
• [Adipose tissues and wound healing]
• [Analysis of the poly-genes expression changes in liver by gene expression profile chip in gut ischemia-reperfusion rats]
• [Bifidobacterial supplement enhances the expression and excretion of intestinal sIgA in severely burned rats]
• [Changes in the percentage of human leukocyte antigen DR in CD(+)(14) monocytes in burned patients]
• [Changes in uncoupling protein-2, 3 mRNA expression in the scalded rats after escharectomy at different post scalding stages]
• [Clinical study of unrelated umbilical cord blood transplantation in 32 children patients]
• [Development of morphological and functional research on alveolar epithelial type II cell]
• [Diagnostic criterion and management of burn sepsis]
• [Effect of local mild hypothermia on expression of aquaporin-4 following intracerebral hemorrhage in rats]
• [Effect of radix Angelicae sinensis decoction for supplementing blood on inhibiting the increase of endothelial cell monolayer permeability induced by hypoosmotic solution]
• [Effects of carbachol on apoptosis of peripheral white blood cells and expression of cytokines in rats suffering from gut ischemia/reperfusion injury.]
• [Effects of efferent vagus nerve excitation on inflammatory response in heart tissue in rats with endotoxemia]
• [Effects of escharectomy during shock stage on the plasma lipid and serum free fatty acid levels in scalded rats]
• [Effects of ethyl pyruvate on cell-mediated immune function in rats with delayed resuscitation after burn injury.]
• [Enteral administration of carbachol on systemic inflammatory response and multiple organ dysfunction induced by partial ischemia/reperfusion injury to the gut.]
• [Gene expression of extracellular-signal regulated protein kinase 1/2 and their MAPKKs in hypertrophic scars]
• [High mobility group box-1 protein activates Janus kinase-signal transducer and activator of transcription pathway in rat peritoneal macrophages]
• [Influence of carbachol on intestinal dysfunction after traumatic or burn injury]
• [Measurement of isotope shift by means of laser optogalvanic spectroscopy]
• [Relationship between keloid proliferation and apoptosis of epithelial cell with destruction of structure and function of skin appendages]
• [Research progress in anti-inflammation of vagus nerve and neurotransmitter Ach]
• [Rights maintenance and self-discipline of practicing dentist: Part I. Defect of responsibility in medical dispute]
• [The potential role of high mobility group-1 protein in the pathogenesis of sepsis-induced multiple organ dysfunction syndrome in rats]
• [The protective effect of supplementation of probiotics combined with riboflavin on the intestinal barrier of the rats after scald injury]
• [The significance and the expression of homeobox genes during human burn wound healing]
• [To be a qualified burn surgeon--a senior old doctor's words]
• [Update in our understanding of intracellular signaling pathways in sepsis]