Bidirectional MHC molecule exchange between migratory and resident dendritic cells.

Bidirectional MHC molecule exchange between migratory and resident dendritic cells. Research Abstract Details 

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Bidirectional MHC molecule exchange between migratory and resident dendritic cells. Abstract Text:

Magali de Heusch,Didier Blocklet,Dominique Egrise,Bernard Hauquier,Marjorie Vermeersch,Serge Goldman,Muriel Moser,Magali de Heusch,Didier Blocklet,Dominique Egrise,Bernard Hauquier,Marjorie Vermeersch,Serge Goldman,Muriel Moser,

Dendritic cells (DCs) loaded extracorporeally with antigen can be used as an adjuvant in vivo. In this work, we analyzed the migration of transferred DC and monitored the phenotype of new migrants in the draining lymph nodes. It is surprising that we found that a majority of resident DCs expressed donor MHC molecules and that a proportion of injected DCs acquired host MHC molecules. These observations suggest that a bidirectional MHC molecule exchange occurs between migratory and resident DCs, a mechanism that may amplify antigen presentation in vivo.

Bidirectional MHC molecule exchange between migratory and resident dendritic cells. Publishing Authors By Initials

M de Heusch,D Blocklet,D Egrise,B Hauquier,M Vermeersch,S Goldman,M Moser,M de Heusch,D Blocklet,D Egrise,B Hauquier,M Vermeersch,S Goldman,M Moser,

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Bidirectional MHC molecule exchange between migratory and resident dendritic cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of leukocyte biology

VOLUME: 82

Page Numbers: 861-8

Journal Abbreviation: J. Leukoc. Biol.

ISSN: 0741-5400

DAY: 18

MONTH: 07

YEAR: 2007

Bidirectional MHC molecule exchange between migratory and resident dendritic cells. Information

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LANGUAGE: eng

NlmUniqueID: 8405628

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AFFILIATION: Institut de Biologie et Médecine Moléculaires, Université Libre de Bruxelles, Rue des Prof. Jeener et Brachet 12, 6041 Gosselies, Belgium.

Country: United States

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MEDLINETA: J Leukoc Biol

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