Biased expression of variable region gene families of the immunoglobulin heavy chain in autoimmune-prone mice.

Biased expression of variable region gene families of the immunoglobulin heavy chain in autoimmune-prone mice. Research Abstract Details 

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Biased expression of variable region gene families of the immunoglobulin heavy chain in autoimmune-prone mice. Abstract Text:

Y Yaoita,M Takahashi,C Azuma,Y Kanai,T Honjo,

We have examined usage of variable region gene families of the immunoglobulin heavy chain (VH gene family) in spleens of MRL/MpJ-1pr/lpr (MRL/lpr), (NZB x NZW)F1, and BXSB mice by Northern analysis using various VH probes, including the VHPAR gene which we cloned and identified as a gene encoding the heavy-chain variable region of antipoly(ADP-ribose) antibody. The amount of VHS107 family mRNA was almost constant for the same amount of splenic crude RNA in autoimmune-prone and normal mice, while concentrations of other family mRNAs were elevated in autoimmune-prone mice. For example, per splenic RNA the VHPAR family was expressed in MRL/lpr mice 10 times more than in their normal counterpart, MRL/MpJ-+/+ (MRL/+) mice. These results indicate the bias of VH gene usage in autoimmune-prone mice. Expression of the VHS107 family was depressed from an early life stage of MRL/lpr and male BXSB mice. Furthermore, the expression of IL-4 and IL-5 were quantitatively compared, as B cell differentiation factor was thought to be produced by abnormally proliferative T cells in lymph nodes of MRL/lpr mice. We could not, however, observe overproduction of IL-4 and IL-5 mRNA in the lymph nodes.

Biased expression of variable region gene families of the immunoglobulin heavy chain in autoimmune-prone mice. Publishing Authors By Initials

Y Yaoita,M Takahashi,C Azuma,Y Kanai,T Honjo,

For similar nucleic acids, nucleotides, and nucleosides: nucleic acids: rna research abstracts see: nucleic acids, nucleotides, and nucleosides: nucleic acids: rna research

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Biased expression of variable region gene families of the immunoglobulin heavy chain in autoimmune-prone mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 104

Page Numbers: 337-43

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Sep

YEAR: 1988

Biased expression of variable region gene families of the immunoglobulin heavy chain in autoimmune-prone mice. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Biased expression of variable region gene families of the immunoglobulin heavy chain in autoimmune-prone mice. Keywords Mesh Terms:

KEYWORDS: RNA

MESH TERMS: isolation & purification

Chemical & Substance for Abstract: Biased expression of variable region gene families of the immunoglobulin heavy chain in autoimmune-prone mice. Information

Substance Name: RNA

Registry Number: 63231-63-0

Grant and Affiliation Information for Biased expression of variable region gene families of the immunoglobulin heavy chain in autoimmune-prone mice.

AFFILIATION: Department of Medical Chemistry, Kyoto University Faculty of Medicine.

Country: JAPAN

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MEDLINETA: J Biochem

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