Biased clustered substitutions in the human genome: the footprints of male-driven biased gene conversion.

Biased clustered substitutions in the human genome: the footprints of male-driven biased gene conversion. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Biased clustered substitutions in the human genome: the footprints of male-driven biased gene conversion. Abstract Text:

Timothy R Dreszer,Gregory D Wall,David Haussler,Katherine S Pollard,

We examined fixed substitutions in the human lineage since divergence from the common ancestor with the chimpanzee, and determined what fraction are AT to GC (weak-to-strong). Substitutions that are densely clustered on the chromosomes show a remarkable excess of weak-to-strong "biased" substitutions. These unexpected biased clustered substitutions (UBCS) are common near the telomeres of all autosomes but not the sex chromosomes. Regions of extreme bias are enriched for genes. Human and chimp orthologous regions show a striking similarity in the shape and magnitude of their respective UBCS maps, suggesting a relatively stable force leads to clustered bias. The strong and stable signal near telomeres may have participated in the evolution of isochores. One exception to the UBCS pattern found in all autosomes is chromosome 2, which shows a UBCS peak midchromosome, mapping to the fusion site of two ancestral chromosomes. This provides evidence that the fusion occurred as recently as 740,000 years ago and no more than approximately 3 million years ago. No biased clustering was found in SNPs, suggesting that clusters of biased substitutions are selected from mutations. UBCS is strongly correlated with male (and not female) recombination rates, which explains the lack of UBCS signal on chromosome X. These observations support the hypothesis that biased gene conversion (BGC), specifically in the male germline, played a significant role in the evolution of the human genome.

Biased clustered substitutions in the human genome: the footprints of male-driven biased gene conversion. Publishing Authors By Initials

TR Dreszer,GD Wall,D Haussler,KS Pollard,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Biased clustered substitutions in the human genome: the footprints of male-driven biased gene conversion. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Genome research

VOLUME: 17

Page Numbers: 1420-30

Journal Abbreviation: Genome Res.

ISSN: 1088-9051

DAY: 4

MONTH: 09

YEAR: 2007

Biased clustered substitutions in the human genome: the footprints of male-driven biased gene conversion. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9518021

Biased clustered substitutions in the human genome: the footprints of male-driven biased gene conversion. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Biased clustered substitutions in the human genome: the footprints of male-driven biased gene conversion. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Biased clustered substitutions in the human genome: the footprints of male-driven biased gene conversion.

AFFILIATION: Department of Biomolecular Engineering, University of California, Santa Cruz, California 95064, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Genome Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Biased clustered substitutions in the human genome: the footprints of male-driven biased gene conversion Related Publications

• A new combination haemophilus influenzae type B and Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine for primary immunization of infants.
• Bayesian analysis of fiber impedance measurements.
• Biased clustered substitutions in the human genome: the footprints of male-driven biased gene conversion.
• Blood transfusion; the indications its technique and dangers.
• Children's participation in vaccine research: parents' views.
• Emerging treatments for viral retinitis.
• Estradiol-17beta regulates mouse uterine epithelial cell proliferation through insulin-like growth factor 1 signaling.
• INJURIES IN AUSTRALIAN RULES FOOTBALL: A Review of the Literature.
• Incorporation of newly synthesized fatty acids into cytosolic glycerolipids in pea leaves occurs via acyl editing.
• MANAGEMENT OF ACHILLES TENDON DISORDERS: A Case Review.
• Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland.
• Macrophages regulate the angiogenic switch in a mouse model of breast cancer.
• Modern dressings: must do better.
• Optimisation and validation of a medium-throughput electrophysiology-based hNav1.5 assay using IonWorkstrade mark.
• Peptic ulcer following splanchnicectomy; a report of 13 cases.
• Pharmacological validation of a semi-automated in vitro hippocampal brain slice assay for assessment of seizure liability.
• Polymerization kinetics of ADP- and ADP-Pi-actin determined by fluorescence microscopy.
• Progesterone blocks estrogen-induced DNA synthesis through the inhibition of replication licensing.
• Promoting healthy survivorship.
• Reconsideration of the use of meningococcal polysaccharide vaccine.
• Reduced expression of decay-accelerating factor 1 on CD4+ T cells in murine systemic autoimmune disease.
• Regulation of actin filament assembly by Arp2/3 complex and formins.
• SPONDYLOLYSIS IN A PROFESSIONAL FAST BOWLER: A Case Study.
• Single molecule kinetic analysis of actin filament capping. Polyphosphoinositides do not dissociate capping proteins.
• Solastalgia: the distress caused by environmental change.
• Studies of bromine-oxidizable sulfur-containing compounds in mold metabolism.
• The occurrence of gastric neoplasms in youth.
• The virologic, immunologic, and clinical effects of interleukin 2 with potent antiretroviral therapy in patients with moderately advanced human immunodeficiency virus infection: a randomized controlled clinical trial--AIDS Clinical Trials Group 328.
• Tumor-associated macrophages press the angiogenic switch in breast cancer.
• W135 in Africa: origins, problems and perspectives.