[Bi-weekly irinotecan hydrochloride and Cisplatin as a second-line chemotherapy for patients with advanced gastric cancer.]

[Bi-weekly irinotecan hydrochloride and Cisplatin as a second-line chemotherapy for patients with advanced gastric cancer.] Research Abstract Details 

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[Bi-weekly irinotecan hydrochloride and Cisplatin as a second-line chemotherapy for patients with advanced gastric cancer.] Abstract Text:

Shuji Suzuki,Nobuhiko Harada,Yasuyoshi Takeo,Seiichi Tanaka,Tsuneo Hayashi,Mamoru Suzuki,Fujio Hanyu,Shuji Suzuki,Nobuhiko Harada,Yasuyoshi Takeo,Seiichi Tanaka,Tsuneo Hayashi,Mamoru Suzuki,Fujio Hanyu,Shuji Suzuki,Nobuhiko Harada,Yasuyoshi Takeo,Seiichi Tanaka,Tsuneo Hayashi,Mamoru Suzuki,Fujio Hanyu,

Purpose: To evaluate the effectiveness of bi-weekly administered irinotecan (CPT-11) and Cisplatin (CDDP) as a second-line chemotherapy for patients with advanced gastric cancer. Methods: We included 22 patients who were resistant to 5-fluorouracil (5-FU) -based chemotherapy. CPT-11 (80 mg/m (2)) and CDDP (25 mg/m(2)) were administered bi-weekly on days 1 and 15 of a 4-week-cycle, on an outpatient basis except for the first time. Outcome variables include tumor response, toxicity, and survival. Results: Among all patients, 8 responded to the therapy, yielding an overall response rate of 36.4% (complete response, n=1; partial response, n=7), while 14 did not respond (stable disease, n=9; progressive disease, n=5). The time to progression was 5.3 months, and the median survival was 10.6 months. Adverse reactions included Grade 3 or 4 leucopenia (n=4; 18.2%), Grade 3 or 4 thrombocytopenia (n=1; 4.5%) but all of these patients recovered soon (within one week). Conclusion: Bi-weekly CPT-11 and CDDP treatment was effective and should be considered as a second-line chemotherapy for patients with advanced gastric cancer who are resistant to 5-FU based chemotherapy.

[Bi-weekly irinotecan hydrochloride and Cisplatin as a second-line chemotherapy for patients with advanced gastric cancer.] Publishing Authors By Initials

S Suzuki,N Harada,Y Takeo,S Tanaka,T Hayashi,M Suzuki,F Hanyu,S Suzuki,N Harada,Y Takeo,S Tanaka,T Hayashi,M Suzuki,F Hanyu,S Suzuki,N Harada,Y Takeo,S Tanaka,T Hayashi,M Suzuki,F Hanyu,

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[Bi-weekly irinotecan hydrochloride and Cisplatin as a second-line chemotherapy for patients with advanced gastric cancer.] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Gan to kagaku ryoho. Cancer & chemotherapy

VOLUME: 34

Page Numbers: 2245-8

Journal Abbreviation: Gan To Kagaku Ryoho

ISSN: 0385-0684

DAY: 14

MONTH: Dec

YEAR: 2007

[Bi-weekly irinotecan hydrochloride and Cisplatin as a second-line chemotherapy for patients with advanced gastric cancer.] Information

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LANGUAGE: jpn

NlmUniqueID: 7810034

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AFFILIATION: Hachioji Digestive Disease Hospital.

Country: Japan

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MEDLINETA: Gan To Kagaku Ryoho

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