Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity.

Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity. Research Abstract Details 

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Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity. Abstract Text:

BACKGROUND: Knowledge of how synapses alter their efficiency of communication is central to the understanding of learning and memory. The most extensively studied forms of synaptic plasticity are long-term potentiation (LTP) and its counterpart long-term depression (LTD) of AMPA receptor-mediated synaptic transmission. In the CA1 region of the hippocampus, it has been shown that LTP often involves a rapid increase in the unitary conductance of AMPA receptor channels. However, LTP can also occur in the absence of any alteration in AMPA receptor unitary conductance. In the present study we have used whole-cell dendritic recording, failures analysis and non-stationary fluctuation analysis to investigate the mechanism of depotentiation of LTP. RESULTS: We find that when LTP involves an increase in unitary conductance, subsequent depotentiation invariably involves the return of unitary conductance to pre-LTP values. In contrast, when LTP does not involve a change in unitary conductance then depotentiation also occurs in the absence of any change in unitary conductance, indicating a reduction in the number of activated receptors as the most likely mechanism. CONCLUSIONS: These data show that unitary conductance can be bi-directionally modified by synaptic activity. Furthermore, there are at least two distinct mechanisms to restore synaptic strength from a potentiated state, which depend upon the mechanism of the previous potentiation.

Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity. Publishing Authors By Initials

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Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: BMC neuroscience

VOLUME: 5

Page Numbers: 44

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ISSN: 1471-2202

DAY: 11

MONTH: 11

YEAR: 2004

Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity. Information

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LANGUAGE: eng

NlmUniqueID: 100966986

Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity. Keywords Mesh Terms:

KEYWORDS: Receptors, N-Methyl-D-Aspartate

MESH TERMS: physiology

Chemical & Substance for Abstract: Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity. Information

Substance Name: Receptors, N-Methyl-D-Aspartate

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Grant and Affiliation Information for Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity.

AFFILIATION: MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, BS8 1TD, UK. Andreas.Luthi@fmi.ch <Andreas.Luthi@fmi.ch>

Country: England

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MEDLINETA: BMC Neurosci

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