Beyond SHM and CSR: AID and related cytidine deaminases in the host response to viral infection.

Beyond SHM and CSR: AID and related cytidine deaminases in the host response to viral infection. Research Abstract Details 

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Beyond SHM and CSR: AID and related cytidine deaminases in the host response to viral infection. Abstract Text:

Brad R Rosenberg,F Nina Papavasiliou,

As the primary effector of immunoglobulin somatic hypermutation (SHM) and class switch recombination (CSR), activation-induced cytidine deaminase (AID) serves an important function in the adaptive immune response. Recent advances have demonstrated that AID and a group of closely related cytidine deaminases, the APOBEC3 proteins, also act in the innate host response to viral infection. Antiviral activity was first attributed to APOBEC3G as a potent inhibitor of HIV. It is now apparent that the targets of the APOBEC3 proteins extend beyond HIV, with family members acting against a wide variety of viruses as well as host-encoded retrotransposable genetic elements. Although it appears to function through a different mechanism, AID also possesses antiviral properties. Independent of its antibody diversification functions, AID protects against transformation by Abelson murine leukemia virus (Ab-MLV), an oncogenic retrovirus. Additionally, AID has been implicated in the host response to other pathogenic viruses. These emerging roles for the AID/APOBEC cytidine deaminases in viral infection suggest an intriguing evolutionary connection of innate and adaptive immune mechanisms.

Beyond SHM and CSR: AID and related cytidine deaminases in the host response to viral infection. Publishing Authors By Initials

BR Rosenberg,FN Papavasiliou,

For similar virus diseases research abstracts see: virus diseases research

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Beyond SHM and CSR: AID and related cytidine deaminases in the host response to viral infection. Journal Published:

PUBLICATION TYPE: Review

Journal: Advances in immunology

VOLUME: 94

Page Numbers: 215-44

Journal Abbreviation: Adv. Immunol.

ISSN: 0065-2776

DAY: 3

MONTH: 12

YEAR: 2007

Beyond SHM and CSR: AID and related cytidine deaminases in the host response to viral infection. Information

Number of References: 130

LANGUAGE: eng

NlmUniqueID: 370425

Beyond SHM and CSR: AID and related cytidine deaminases in the host response to viral infection. Keywords Mesh Terms:

KEYWORDS: Virus Diseases

MESH TERMS: immunology

Chemical & Substance for Abstract: Beyond SHM and CSR: AID and related cytidine deaminases in the host response to viral infection. Information

Substance Name: Cytidine Deaminase

Registry Number: EC 3.5.4.5

Grant and Affiliation Information for Beyond SHM and CSR: AID and related cytidine deaminases in the host response to viral infection.

AFFILIATION: Laboratory of Lymphocyte Biology, The Rockefeller University, New York, New York, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM07739

ACRONYM: GM

MEDLINETA: Adv Immunol

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