Beyond raloxifene for the prevention of osteoporosis and breast cancer.

Beyond raloxifene for the prevention of osteoporosis and breast cancer. Research Abstract Details 

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Beyond raloxifene for the prevention of osteoporosis and breast cancer. Abstract Text:

Selective oestrogen receptor modulators (SERMs) can build bone in the postmenopausal woman and lower circulating cholesterol. These oestrogen-like properties contrast with the anti-oestrogenic properties observed in the breast where SERMs inhibit the oestrogen-mediated development and growth of ER positive breast cancers. The two clinically useful SERMs, tamoxifen and its chemical cousin raloxifene, are currently used successfully either for the treatment and prevention of breast cancer (tamoxifen) or the treatment and prevention of osteoporosis (raloxifene). However, raloxifene has the beneficial side-effect of breast cancer prevention. These multifunction medicines provide proof of concept that novel molecules can be selectively targeted to diseases mediated by the endocrine system.

Beyond raloxifene for the prevention of osteoporosis and breast cancer. Publishing Authors By Initials

For similar hormones, hormone substitutes, and hormone antagonists: hormone antagonists: estrogen receptor modulators: selective estrogen receptor modulators research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormone antagonists: estrogen receptor modulators: selective estrogen receptor modulators research

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Beyond raloxifene for the prevention of osteoporosis and breast cancer. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: British journal of pharmacology

VOLUME: 150

Page Numbers: 3-4

Journal Abbreviation: Br. J. Pharmacol.

ISSN: 0007-1188

DAY: 20

MONTH: 11

YEAR: 2006

Beyond raloxifene for the prevention of osteoporosis and breast cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7502536

Beyond raloxifene for the prevention of osteoporosis and breast cancer. Keywords Mesh Terms:

KEYWORDS: Selective Estrogen Receptor Modulators

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Beyond raloxifene for the prevention of osteoporosis and breast cancer. Information

Substance Name: Raloxifene

Registry Number: 84449-90-1

Grant and Affiliation Information for Beyond raloxifene for the prevention of osteoporosis and breast cancer.

AFFILIATION: Fox Chase Cancer Center, 333 East Cottman Avenue, Philadelphia, PA 19111, USA. v.craig.jordan@fccc.edu

Country: England

AGENCY: United States NIGMS

GRANT: R01 GM067156

ACRONYM: GM

MEDLINETA: Br J Pharmacol

REFSOURCE: Br J Pharmacol. 2007 Jan;150(1):19-28

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