Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia.

Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia. Research Abstract Details 

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Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia. Abstract Text:

B C Schwahn,X-L Wang,L G Mikael,Q Wu,J Cohn,H Jiang,K N Maclean,R Rozen,B C Schwahn,X-L Wang,L G Mikael,Q Wu,J Cohn,H Jiang,K N Maclean,R Rozen,

OBJECTIVE: To investigate the lipotropic action of betaine on plasma lipoproteins and tissue lipids. METHODS AND RESULTS: Adult mice, wild type (+/+) or heterozygous (+/-) for a disruption of the methylenetetrahydrofolate reductase (Mthfr) gene, were supplemented with betaine for 1 year and compared with mice on control diets. Outcome measures were plasma homocysteine and lipoprotein levels, aortic and liver morphology, and liver staining for 3-nitrotyrosine (oxidative stress marker) and Apolipoprotein A-I (ApoA-I). We also investigated short-term effects of supplemental betaine on plasma lipoproteins in Mthfr +/+ and +/- mice. Both genotypes showed significantly lower plasma homocysteine after long-term betaine supplementation, and lower plasma triglycerides and higher HDL-cholesterol after both short- and long-term betaine. Lipid accumulation in liver and aortic wall tended to be lower in Mthfr+/+ compared to Mthfr+/- mice and in betaine-supplemented compared to unsupplemented mice. Nitrotyrosine staining was higher and ApoA-I staining was lower in livers of Mthfr+/- compared to Mthfr+/+ mice. Betaine did not affect staining of nitrotyrosine but increased ApoA-I staining. A significant negative correlation was observed between plasma homocysteine and liver ApoA-I. CONCLUSIONS: Mild MTHFR deficiency in mice is associated with increased risk for atherosclerotic disease. Betaine has a lipotropic effect, which is associated with a reduction in homocysteine, an increase in ApoA-I and an amelioration of the atherogenic risk profile.

Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia. Publishing Authors By Initials

BC Schwahn,XL Wang,LG Mikael,Q Wu,J Cohn,H Jiang,KN Maclean,R Rozen,BC Schwahn,XL Wang,LG Mikael,Q Wu,J Cohn,H Jiang,KN Maclean,R Rozen,

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Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Atherosclerosis

VOLUME: 195

Page Numbers: e100-7

Journal Abbreviation: Atherosclerosis

ISSN: 0021-9150

DAY: 9

MONTH: 08

YEAR: 2007

Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia. Information

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LANGUAGE: eng

NlmUniqueID: 242543

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Grant and Affiliation Information for Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia.

AFFILIATION: Departments of Human Genetics and Pediatrics, McGill University Health Center-Montreal Children's Hospital, Montreal, Canada.

Country: Ireland

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MEDLINETA: Atherosclerosis

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