Beta-phenylethylamine inhibits K+ currents in neocortical neurons of the rat: a possible mechanism of beta-phenylethylamine-induced seizures.

Beta-phenylethylamine inhibits K+ currents in neocortical neurons of the rat: a possible mechanism of beta-phenylethylamine-induced seizures. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Beta-phenylethylamine inhibits K+ currents in neocortical neurons of the rat: a possible mechanism of beta-phenylethylamine-induced seizures. Abstract Text:

beta-Phenylethylamine (beta-PEA), an endogenous amine synthesized in the brain, serves as a neuromodulator and is involved in the pathophysiology of various neurological disorders such as depression, schizophrenia, and attention-deficit hyperactivity disorder. beta-PEA fully exerts the physiological effects within the nanomolar concentration range via the trace amine receptors, but beta-PEA also causes convulsions at much higher concentrations via an as yet unknown mechanism. To investigate the electrophysiological mechanism by which beta-PEA induces convulsions, we examined the effect of beta-PEA on ionic currents passing through the cell membrane of dissociated rat cerebral cortical neurons, using a patch-clamp technique. The external application of beta-PEA suppressed ionic currents which continuously flowed when the membrane potential was held at -25 mV. The suppression was in a concentration-dependent manner and a half-maximal effective concentration was 540 muM. These currents suppressed by beta-PEA consisted of two K(+) currents: a time- and voltage-dependent K(+) current (M-current) and a leakage K(+) current. The suppression of the M-current reduces the efficacy of the current in limiting excessive neuronal firing, and the suppression of the leakage K(+) current can cause membrane depolarization and thus promote neuronal excitation. Reducing both of these currents in concert may produce neuronal seizing activity, which could conceivably underlie the convulsions induced by high-dose beta-PEA.

Beta-phenylethylamine inhibits K+ currents in neocortical neurons of the rat: a possible mechanism of beta-phenylethylamine-induced seizures. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Beta-phenylethylamine inhibits K+ currents in neocortical neurons of the rat: a possible mechanism of beta-phenylethylamine-induced seizures. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Tohoku journal of experimental medicine

VOLUME: 215

Page Numbers: 333-40

Journal Abbreviation: Tohoku J. Exp. Med.

ISSN: 1349-3329

DAY: 5

MONTH: Aug

YEAR: 2008

Beta-phenylethylamine inhibits K+ currents in neocortical neurons of the rat: a possible mechanism of beta-phenylethylamine-induced seizures. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 417355

Beta-phenylethylamine inhibits K+ currents in neocortical neurons of the rat: a possible mechanism of beta-phenylethylamine-induced seizures. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Beta-phenylethylamine inhibits K+ currents in neocortical neurons of the rat: a possible mechanism of beta-phenylethylamine-induced seizures. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Beta-phenylethylamine inhibits K+ currents in neocortical neurons of the rat: a possible mechanism of beta-phenylethylamine-induced seizures.

AFFILIATION: Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan.

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Tohoku J Exp Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Beta-phenylethylamine inhibits K+ currents in neocortical neurons of the rat: a possible mechanism of beta-phenylethylamine-induced seizures Related Publications

• A case of Fukuyama-type congenital muscular dystrophy with a very mild mental deficit.
• Antibacterial activity of hydroxychalcone against methicillin-resistant Staphylococcus aureus.
• Beta-phenylethylamine inhibits K+ currents in neocortical neurons of the rat: a possible mechanism of beta-phenylethylamine-induced seizures.
• Hypercalcemia due to all-trans retinoic acid therapy for acute promyelocytic leukemia: a case report of effective treatment with bisphosphonate.
• Hypophosphatemia in juvenile patients with systemic lupus erythematosus.
• Laxative effect of agarwood leaves and its mechanism.
• Polysulfanes in the volatile oils of ferula species.
• Proceedings: EEG findings in inborn errors of metabolism.
• Refractory autoimmune hemolytic anemia in a patient with chromosome 22q11.2 deletion syndrome.
• Resveratrol tetramers with a C6-C3 or a C1 unit from Upuna borneensis.
• Spike orientation may predict epileptogenic side across cerebral sulci containing the estimated equivalent dipole.
• The histology of the lung in neonates with tricuspid valve disease and gross cardiomegaly due to severe regurgitation.
• VECTOR-ELECTRO-OCULOGRAPHY AND ITS CLINICAL APPLICATION. TWO-DIMENSIONAL RECORDING OF EYE MOVEMENTS.
• [Enactment of TR14969:2007-Quality Management System for Medical Devices; Guide to the Application of JIS Q 13485:2005.]
• [Pathophysiology and laboratory findings of measles]