beta-Lactotensin, a neurotensin agonist peptide derived from bovine beta-lactoglobulin, enhances memory consolidation in mice.

beta-Lactotensin, a neurotensin agonist peptide derived from bovine beta-lactoglobulin, enhances memory consolidation in mice. Research Abstract Details 

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beta-Lactotensin, a neurotensin agonist peptide derived from bovine beta-lactoglobulin, enhances memory consolidation in mice. Abstract Text:

Kousaku Ohinata,Soushi Sonoda,Natsumi Inoue,Rena Yamauchi,Keiji Wada,Masaaki Yoshikawa,

beta-Lactotensin (His-Ile-Arg-Leu) is an ileum-contracting tetrapeptide isolated from bovine beta-lactoglobulin. We previously reported that a neurotensin agonist beta-lactotensin shows antinociceptive effect through neurotensin NT(2) receptor. We found that centrally or orally administered beta-lactotensin at a dose of 60nmol/mouse or 300-500mg/kg, respectively, increased memory consolidation in the step-through-type inhibitory avoidance test in mice. The memory-enhancing activity of beta-lactotensin was inhibited by the dopamine D(2) receptor antagonist raclopride but not the D(1) receptor antagonist SCH23390. Taken together, beta-lactotensin might improve memory consolidation through activating the dopamine D(2) receptor.

beta-Lactotensin, a neurotensin agonist peptide derived from bovine beta-lactoglobulin, enhances memory consolidation in mice. Publishing Authors By Initials

K Ohinata,S Sonoda,N Inoue,R Yamauchi,K Wada,M Yoshikawa,

For similar proteins: membrane proteins: receptors, cell surface: receptors, biogenic amine: receptors, catecholamine: receptors, dopamine: receptors, dopamine d2 research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, biogenic amine: receptors, catecholamine: receptors, dopamine: receptors, dopamine d2 research

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beta-Lactotensin, a neurotensin agonist peptide derived from bovine beta-lactoglobulin, enhances memory consolidation in mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Peptides

VOLUME: 28

Page Numbers: 1470-4

Journal Abbreviation: Peptides

ISSN: 0196-9781

DAY: 8

MONTH: 06

YEAR: 2007

beta-Lactotensin, a neurotensin agonist peptide derived from bovine beta-lactoglobulin, enhances memory consolidation in mice. Information

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LANGUAGE: eng

NlmUniqueID: 8008690

beta-Lactotensin, a neurotensin agonist peptide derived from bovine beta-lactoglobulin, enhances memory consolidation in mice. Keywords Mesh Terms:

KEYWORDS: Receptors, Dopamine D2

MESH TERMS: metabolism

Chemical & Substance for Abstract: beta-Lactotensin, a neurotensin agonist peptide derived from bovine beta-lactoglobulin, enhances memory consolidation in mice. Information

Substance Name: beta-lactotensin

Registry Number: 0

Grant and Affiliation Information for beta-Lactotensin, a neurotensin agonist peptide derived from bovine beta-lactoglobulin, enhances memory consolidation in mice.

AFFILIATION: Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto 611-0011, Japan.

Country: United States

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MEDLINETA: Peptides

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• beta-Lactotensin, a neurotensin agonist peptide derived from bovine beta-lactoglobulin, enhances memory consolidation in mice.