beta-Lactam congeners of orlistat as inhibitors of fatty acid synthase.

beta-Lactam congeners of orlistat as inhibitors of fatty acid synthase. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

beta-Lactam congeners of orlistat as inhibitors of fatty acid synthase. Abstract Text:

Wei Zhang,Robyn D Richardson,Supakarn Chamni,Jeffrey W Smith,Daniel Romo,Wei Zhang,Robyn D Richardson,Supakarn Chamni,Jeffrey W Smith,Daniel Romo,

beta-Lactam derivatives of orlistat were prepared and their inhibitory activities toward the thioesterase domain of fatty acid synthase (FAS-TE) were evaluated using a recombinant form of the enzyme. While in general these derivatives showed lower potency compared to beta-lactones, a reasonably potent, lead compound (-)-9 (IC(50)=8.6muM) was discovered that suggests that this class of compounds should be evaluated further.

beta-Lactam congeners of orlistat as inhibitors of fatty acid synthase. Publishing Authors By Initials

W Zhang,RD Richardson,S Chamni,JW Smith,D Romo,W Zhang,RD Richardson,S Chamni,JW Smith,D Romo,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

beta-Lactam congeners of orlistat as inhibitors of fatty acid synthase. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 18

Page Numbers: 2491-4

Journal Abbreviation:

ISSN: 1464-3405

DAY: 19

MONTH: 02

YEAR: 2008

beta-Lactam congeners of orlistat as inhibitors of fatty acid synthase. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107377

beta-Lactam congeners of orlistat as inhibitors of fatty acid synthase. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: beta-Lactam congeners of orlistat as inhibitors of fatty acid synthase. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for beta-Lactam congeners of orlistat as inhibitors of fatty acid synthase.

AFFILIATION: Department of Chemistry, Texas A&M University, College Station, TX 77842-3012, USA.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Bioorg Med Chem Lett

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

beta-Lactam congeners of orlistat as inhibitors of fatty acid synthase Related Publications

• Concise synthesis of spirocyclic, bridged gamma-butyrolactones via stereospecific, dyotropic rearrangements of beta-lactones involving 1,2-acyl and delta-lactone migrations.
• Concise total synthesis of (+/-)-salinosporamide A, (+/-)-cinnabaramide A, and derivatives via a bis-cyclization process: implications for a biosynthetic pathway?
• Diastereoselective Synthesis of Tetrahydrofurans via Mead Reductive Cyclization of Keto-beta-Lactones Derived from the Tandem Mukaiyama Aldol Lactonization (TMAL) Process.
• Diastereoselective, vinylogous mukaiyama aldol additions of silyloxy furans to cyclic ketones: annulation of butenolides and gamma-lactones.
• Effect of a push-pull perfusion of carbachol on the pontine reticular formation multiple unit activity.
• Enantioselective synthesis of (+)-monobromophakellin and (+)-phakellin: a concise phakellin annulation strategy applicable to Palau'amine.
• Enantioselective total synthesis of (+)-dibromophakellstatin.
• Facile Synthesis of the Trans-Fused Azabicyclo[3.3.0]octane Core of the Palau'amines and the Tricyclic Core of the Axinellamines from a Common Intermediate.
• Highly diastereoselective, tandem, three-component synthesis of tetrahydrofurans from ketoaldehydes via silylated beta-lactone intermediates.
• Neural correlates of a postponed decision report.
• Neuronal activity in the monkey striatum during the initiation of movements.
• Perceptual detection as a dynamical bistability phenomenon: a neurocomputational correlate of sensation.
• Practical, catalytic, asymmetric synthesis of beta-lactones via a sequential ketene dimerization/hydrogenation process: inhibitors of the thioesterase domain of fatty acid synthase.
• Push-pull perfusion of pentylenetetrazol in the brain stem of 'encéphale isolé' cats.
• Role of primary somatic sensory cortex in the categorization of tactile stimuli: effects of lesions.
• Role of primate basal ganglia and frontal cortex in the internal generation of movements. I. Preparatory activity in the anterior striatum.
• Simultaneous arming and structure/activity studies of natural products employing O-H insertions: an expedient and versatile strategy for natural products-based chemical genetics.
• Single-stage BAHA implantation in adults and children: Is it safe?
• Specific and non-specific multiple unit activities during pentylenetetrazol seizures in animals with mesencephalic transections.
• Specific and non-specific multiple unit activities during pentylenetetrazol seizures. I. Animals with 'encéphale isolé'.
• Synthesis, characterization, and utility of thermoresponsive natural/unnatural product macroligands for affinity chromatography.
• Synthesis, structure, and reactivity of unexpectedly stable spiroepoxy-beta-lactones obtained by epoxidation of 4-alkylidene-2-oxetanones.
• Total synthesis and comparative analysis of orlistat, valilactone, and a transposed orlistat derivative: Inhibitors of fatty acid synthase.
• Transformation of fused bicyclic and tricyclic beta-lactones to fused gamma-lactones and 3(2H)-furanones via ring expansions and O-H insertions.
• [In Process Citation]
• beta-Lactam congeners of orlistat as inhibitors of fatty acid synthase.