Beta-endorphin levels in longtailed and pigtailed macaques vary by abnormal behavior rating and sex.

Beta-endorphin levels in longtailed and pigtailed macaques vary by abnormal behavior rating and sex. Research Abstract Details 

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Beta-endorphin levels in longtailed and pigtailed macaques vary by abnormal behavior rating and sex. Abstract Text:

Carolyn M Crockett,Gene P Sackett,Curt A Sandman,Aleksandra Chicz-DeMet,Kathleen L Bentson,Carolyn M Crockett,Gene P Sackett,Curt A Sandman,Aleksandra Chicz-DeMet,Kathleen L Bentson,

Frequent or severe abnormal behavior may be associated with the release of endorphins that positively reinforce the behavior with an opiate euphoria or analgesia. One line of research exploring this association involves the superhormone, proopiomelanocortin (POMC). The products of POMC appear to be dysregulated in some human subjects who exhibit self-injurious behavior (SIB). Macaque monkeys have POMC very similar to humans, and some laboratory macaques display SIB or frequent stereotypies. We investigated associations between plasma levels of three immunoreactive POMC fragments with possible opioid action and abnormal behavior ratings in macaques. In 58 adult male and female macaques (24 Macaca fascicularis and 34 Macaca nemestrina), plasma levels of intact beta-endorphin (betaE) and the N-terminal fragment (BEN) were significantly higher in animals with higher levels of abnormal behavior. The C-terminal fragment (BEC) was significantly higher in males but unrelated to ratings of abnormal behavior. Levels of ACTH, cortisol, and (betaE-ACTH)/betaE dysregulation index were unrelated to abnormal behavior. None of the POMC products differed significantly by subjects' species, age, or weight. The finding that intact beta-endorphin is positively related to abnormal behavior in two species of macaque is consistent with some previous research on human subjects and nonprimates. The positive relation of the N-terminal fragment of betaE to abnormal behavior is a new finding.

Beta-endorphin levels in longtailed and pigtailed macaques vary by abnormal behavior rating and sex. Publishing Authors By Initials

CM Crockett,GP Sackett,CA Sandman,A Chicz-DeMet,KL Bentson,CM Crockett,GP Sackett,CA Sandman,A Chicz-DeMet,KL Bentson,

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Beta-endorphin levels in longtailed and pigtailed macaques vary by abnormal behavior rating and sex. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Peptides

VOLUME: 28

Page Numbers: 1987-97

Journal Abbreviation: Peptides

ISSN: 0196-9781

DAY: 19

MONTH: 07

YEAR: 2007

Beta-endorphin levels in longtailed and pigtailed macaques vary by abnormal behavior rating and sex. Information

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LANGUAGE: eng

NlmUniqueID: 8008690

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Grant and Affiliation Information for Beta-endorphin levels in longtailed and pigtailed macaques vary by abnormal behavior rating and sex.

AFFILIATION: National Primate Research Center, Box 357330, University of Washington, Seattle, WA 98195-7330, USA. crockett@u.washington.edu

Country: United States

AGENCY: United States NCRR

GRANT: RR00166

ACRONYM: RR

MEDLINETA: Peptides

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