beta-Amyloid Degradation and Alzheimer's Disease.

beta-Amyloid Degradation and Alzheimer's Disease. Research Abstract Details 

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beta-Amyloid Degradation and Alzheimer's Disease. Abstract Text:

Deng-Shun Wang,Dennis W Dickson,James S Malter,

Extensive beta-amyloid (A beta) deposits in brain parenchyma in the form of senile plaques and in blood vessels in the form of amyloid angiopathy are pathological hallmarks of Alzheimer's disease (AD). The mechanisms underlying A beta deposition remain unclear. Major efforts have focused on A beta production, but there is little to suggest that increased production of A beta plays a role in A beta deposition, except for rare familial forms of AD. Thus, other mechanisms must be involved in the accumulation of A beta in AD. Recent data shows that impaired clearance may play an important role in A beta accumulation in the pathogenesis of AD. This review focuses on our current knowledge of A beta-degrading enzymes, including neprilysin (NEP), endothelin-converting enzyme (ECE), insulin-degrading enzyme (IDE), angiotensin-converting enzyme (ACE), and the plasmin/uPA/tPA system as they relate to amyloid deposition in AD.

beta-Amyloid Degradation and Alzheimer's Disease. Publishing Authors By Initials

DS Wang,DW Dickson,JS Malter,

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beta-Amyloid Degradation and Alzheimer's Disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomedicine & biotechnology

VOLUME: 2006

Page Numbers: 58406

Journal Abbreviation: J. Biomed. Biotechnol.

ISSN: 1110-7243

DAY: 18

MONTH: 10

YEAR: 2006

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LANGUAGE: eng

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Country: United States

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MEDLINETA: J Biomed Biotechnol

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