Beta-adrenergic receptor genes are associated with arterial stiffness in black and white adults: the bogalusa heart study.

Beta-adrenergic receptor genes are associated with arterial stiffness in black and white adults: the bogalusa heart study. Research Abstract Details 

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Beta-adrenergic receptor genes are associated with arterial stiffness in black and white adults: the bogalusa heart study. Abstract Text:

Wei Chen,Sathanur R Srinivasan,Eric Boerwinkle,Gerald S Berenson,Wei Chen,Sathanur R Srinivasan,Eric Boerwinkle,Gerald S Berenson,

BACKGROUND: Sympathetic nervous activity, which is regulated by the beta-adrenergic receptor (beta-AR), is an important determinant of the arterial wall-stiffening process. This study examines the genetic influence of beta-AR gene polymorphisms (beta(1)-AR Arg389Gly, beta(2)-AR Arg16Gly, and beta(3)-AR Trp64Arg) on arterial stiffness in black and white young adults. METHODS: The study cohort included 366 black and 891 white adults, aged 19 to 44 years, enrolled in the Bogalusa Heart Study. Aorta-femoral pulse-wave velocity (af-PWV) was measured by echo-Doppler in a subsample (n = 614). RESULTS: Pulse pressure and heart rate were significantly associated with af-PWV in both races, but not with the three polymorphisms. The af-PWV values differed significantly among the beta(1)-AR Arg389Gly genotype groups in whites (P = .007) and in the total sample (P = .005), with those who were homozygous for Gly389 showing higher values than those who were homozygous for Arg389, after adjusting for cardiovascular risk factors. The beta(3)-AR Arg64 allele was associated with higher af-PWV values in blacks (P = .022) and in the total sample (P = .015). The beta(2)-AR Arg16 allele was associated with af-PWV only in blacks (P = .020). In multivariate regression analysis for the total sample, age, pulse pressure, heart rate, beta(1)-AR Arg389Gly, beta(3)-AR trp64Gly, and smoking status were, in descending order, associated with af-PWV. Furthermore, af-PWV values significantly increased with the increasing number of beta(1)-AR Gly389, beta(2)-AR Arg16, and beta(3)-AR Arg64 alleles (P for trend = .0003). CONCLUSIONS: These results indicate that the beta-AR gene polymorphisms influence arterial stiffness in black and white young adults in an additive manner.

Beta-adrenergic receptor genes are associated with arterial stiffness in black and white adults: the bogalusa heart study. Publishing Authors By Initials

W Chen,SR Srinivasan,E Boerwinkle,GS Berenson,W Chen,SR Srinivasan,E Boerwinkle,GS Berenson,

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Beta-adrenergic receptor genes are associated with arterial stiffness in black and white adults: the bogalusa heart study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of hypertension : journal of the

VOLUME: 20

Page Numbers: 1251-7

Journal Abbreviation: Am. J. Hypertens.

ISSN: 0895-7061

DAY: 30

MONTH: Dec

YEAR: 2007

Beta-adrenergic receptor genes are associated with arterial stiffness in black and white adults: the bogalusa heart study. Information

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LANGUAGE: eng

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AFFILIATION: Tulane Center for Cardiovascular Health and Department of Epidemiology, Tulane University Health Sciences Center, New Orleans, Louisiana.

Country: United States

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MEDLINETA: Am J Hypertens

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