Berkelic acid, a novel spiroketal with selective anticancer activity from an acid mine waste fungal extremophile.

Berkelic acid, a novel spiroketal with selective anticancer activity from an acid mine waste fungal extremophile. Research Abstract Details 

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Berkelic acid, a novel spiroketal with selective anticancer activity from an acid mine waste fungal extremophile. Abstract Text:

Andrea A Stierle,Donald B Stierle,Kal Kelly,

Berkeley Pit Lake is an abandoned open-pit copper mine filled with 30 billion gallons of acidic, metal-contaminated water. This harsh environment is proving to be a source of unusual microorganisms that produce novel bioactive metabolites. Bioassay-guided fractionation using signal transduction enzyme assays led to the isolation of the novel spiroketal, berkelic acid 1, and of the known gamma-pyrone, spiciferone A 4. Berkelic acid has shown selective, nanomolar activity against OVCAR-3, an ovarian cancer cell line in the National Cancer Institute cell line screen. The isolation and characterization of these compounds are reported here.

Berkelic acid, a novel spiroketal with selective anticancer activity from an acid mine waste fungal extremophile. Publishing Authors By Initials

AA Stierle,DB Stierle,K Kelly,

For similar water research abstracts see: water research

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Berkelic acid, a novel spiroketal with selective anticancer activity from an acid mine waste fungal extremophile. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of organic chemistry

VOLUME: 71

Page Numbers: 5357-60

Journal Abbreviation: J. Org. Chem.

ISSN: 0022-3263

DAY: 7

MONTH: Jul

YEAR: 2006

Berkelic acid, a novel spiroketal with selective anticancer activity from an acid mine waste fungal extremophile. Information

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LANGUAGE: eng

NlmUniqueID: 2985193

Berkelic acid, a novel spiroketal with selective anticancer activity from an acid mine waste fungal extremophile. Keywords Mesh Terms:

KEYWORDS: Water

MESH TERMS: chemistry

Chemical & Substance for Abstract: Berkelic acid, a novel spiroketal with selective anticancer activity from an acid mine waste fungal extremophile. Information

Substance Name: Water

Registry Number: 7732-18-5

Grant and Affiliation Information for Berkelic acid, a novel spiroketal with selective anticancer activity from an acid mine waste fungal extremophile.

AFFILIATION: Department of Chemistry, Montana Tech of University of Montana, Butte, MT 59701, USA. astierle@mtech.edu

Country: United States

AGENCY: United States NCRR

GRANT: P20 RR 16455-04

ACRONYM: RR

MEDLINETA: J Org Chem

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