Benzodiazepines in the treatment of sleep disorders: pharmacokinetic aspects.

Benzodiazepines in the treatment of sleep disorders: pharmacokinetic aspects. Research Abstract Details 

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Benzodiazepines in the treatment of sleep disorders: pharmacokinetic aspects. Abstract Text:

L Dettli,

In order to avoid after-effects during the day, slowly eliminated hypnotic agents should not be used in the treatment of sleep disorders. It has become customary to separate long-acting from short-acting benzodiazepines and to use the (terminal) half-life as the principle of classification. This approach is only justified, however, in the case of quickly absorbed benzodiazepines that have no pharmacologically active metabolites and that exhibit one-compartment disposition kinetics. In contrast, the duration of action of benzodiazepines characterized by marked two-compartment disposition kinetics can only be estimated correctly when the potency and all relevant kinetic parameters of the drug preparation and its pharmacologically active metabolites are considered.

Benzodiazepines in the treatment of sleep disorders: pharmacokinetic aspects. Publishing Authors By Initials

L Dettli,

For similar nervous system diseases: sleep disorders research abstracts see: nervous system diseases: sleep disorders research

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Benzodiazepines in the treatment of sleep disorders: pharmacokinetic aspects. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta psychiatrica Scandinavica. Supplementum

VOLUME: 332

Page Numbers: 9-19

Journal Abbreviation:

ISSN: 0065-1591

DAY: 15

MONTH: 02

YEAR: 1986

Benzodiazepines in the treatment of sleep disorders: pharmacokinetic aspects. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370365

Benzodiazepines in the treatment of sleep disorders: pharmacokinetic aspects. Keywords Mesh Terms:

KEYWORDS: Sleep Disorders

MESH TERMS: drug therapy

Chemical & Substance for Abstract: Benzodiazepines in the treatment of sleep disorders: pharmacokinetic aspects. Information

Substance Name: Benzodiazepines

Registry Number: 0

Grant and Affiliation Information for Benzodiazepines in the treatment of sleep disorders: pharmacokinetic aspects.

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Country: DENMARK

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MEDLINETA: Acta Psychiatr Scand Suppl

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